Nasolacrimal implants and related methods for tear stimulation
A device for inducing production of tears may include a body extending from a proximal end to a distal end. The body may be configured for insertion through a puncta of a subject. The device also may include a stimulus delivery mechanism positioned between the proximal end and the distal end and an induction coil operably coupled to the stimulus delivery mechanism. Further, the device may include an external controller wirelessly coupled to the induction coil for inductively transferring energy to the induction coil.
1. A method for inducing tears, comprising:
inserting a stimulation delivery device through a punctum of a subject so that a faceplate disposed at a proximal end of the stimulation delivery device abuts, and is located external to, the punctum; and
applying a stimulation signal to tissue of a nasolacrimal drainage system via the stimulation delivery device, the stimulation signal being received from an external device via a power receptor at least partially disposed in or on the faceplate to induce tearing in the subject.
2. The method of claim 1 , wherein upon inserting the stimulation delivery device and positioning the stimulation delivery device, no portion of the stimulation delivery device is received within a nasal cavity of the subject.
3. The method of claim 1 , wherein stimulating tissue of a canaliculus of the subject includes exciting at least one of a nasociliary nerve, a supratrochlear nerve, a supraorbital nerve and an infratrochlear nerve to induce tearing from a lacrimal gland of the subject.
4. The method of claim 1 , wherein inserting the stimulation delivery device through the punctum includes directly contacting tissue of the nasolacrimal drainage system of the subject with the stimulation delivery device.
5. The method of claim 1 , wherein the stimulation delivery device includes a conductor.
6. The method of claim 5 , wherein the conductor includes at least one electrode.
7. The method of claim 5 , wherein the conductor is a first conductor and the stimulation delivery device includes at least a second conductor, and wherein the first and at least second conductors form at least one of a cathode, an anode, or a pair of bipolar electrodes.
8. The method of claim 1 , wherein the faceplate includes a radial dimension larger than a radial dimension of a remainder of the stimulation delivery device.
9. The method of claim 1 , further comprising:
radially expanding at least a portion of the stimulation delivery device.
10. The method of claim 1 , wherein the stimulation delivery device includes a lumen extending through the stimulation delivery device.
11. The method of claim 1 , further comprising:
sensing, via a sensor coupled to the stimulation delivery device, one or more biochemical properties of tears.
12. The method of claim 1 , further comprising:
sensing, via a sensor coupled to the stimulation delivery device, placement of the stimulation delivery device.
13. The method of claim 1 , further comprising:
sensing, via a sensor coupled to the stimulation delivery device, operation of the stimulation delivery device.
14. The method of claim 13 , wherein the sensor is configured to detect a degree of conductivity in a nasolacrimal duct of the subject.
15. The method of claim 1 , further comprising:
wirelessly communicating the stimulation signal from an external device to the power receptor.
16. The method of claim 1 , wherein the power receptor includes an induction coil, the method further comprising:
inductively transferring energy to the induction coil.
17. The method of claim 1 , wherein applying the stimulation signal includes delivering stimulation energy to a canaliculus via a conductor.
18. The method of claim 1 , wherein the stimulation delivery device is tapered such that a proximal end has a proximal end diameter and a distal end diameter, wherein the distal end diameter is smaller than the proximal end diameter.
19. The method of claim 1 , wherein the power receptor is disposed in or on the faceplate.
20. The method of claim 1 , wherein the power receptor comprises a photo-active material.
21. The method of claim 1 , wherein the subject is suffering from dry eye.
22. A method for inducing tears, comprising:
inserting a stimulation delivery device through a punctum of a subject so that a faceplate disposed at a proximal end of the stimulation delivery device abuts, and is located external to, the punctum;
transferring energy from an external device to a power receptor of the stimulation delivery device, the power receptor at least partially disposed in or on the faceplate;
wirelessly communicating a stimulation signal from the external device to the stimulation delivery device; and
stimulating tissue of a nasolacrimal drainage system of the subject via energy transferred to the power receptor to induce tearing.
23. The method of claim 22 , further comprising:
positioning the stimulation delivery device solely within a canaliculus of the subject such that no portion of the stimulation delivery device is received within a nasal cavity of the subject.
24. The method of claim 22 , wherein the faceplate includes a radial dimension larger than a radial dimension of a remainder of the stimulation delivery device.
25. The method of claim 22 , wherein the stimulation delivery device includes a lumen extending through the stimulation delivery device.
26. The method of claim 22 , further comprising:
sensing, via a sensor coupled to the stimulation delivery device, one or more biochemical properties of tears, placement of the device, and operation of the stimulation delivery device.
27. The method of claim 22 , further comprising:
radially expanding at least a portion of the stimulation delivery device.
28. The method of claim 27 , wherein the portion includes an expandable mesh.
29. The method of claim 22 , wherein stimulating tissue of a canaliculus of the subject includes exciting at least one of a nasociliary nerve, a supratrochlear nerve, a supraorbital nerve and an infratrochlear nerve to induce tearing from a lacrimal gland of the subject.
30. The method of claim 22 , wherein the power receptor is disposed in or on the faceplate.
31. The method of claim 22 , wherein the power receptor comprises a photo-active material.
32. The method of claim 22 , wherein the subject is suffering from dry eye.