Pyrrolobenzodiazepines and targeted conjugates
View Patent ↗A compound, or a pharmaceutically acceptable salt or solvate thereof, or conjugates thereof, selected from the group consisting of: wherein: (a) R 10 is H, and R 11 is OH, OR A , where R A is saturated C 1-4 alkyl; (b) R 10 and R 11 form a nitrogen-carbon double bond between the nitrogen and carbon atoms to which they are bound; or (c) R 10 is H and R 11 is SO z M, where z is 2 or 3 and M is a monovalent pharmaceutically acceptable cation, or both M together are a divalent pharmaceutically acceptable cation.
1. A compound, or a pharmaceutically acceptable salt thereof, selected from the group consisting of:
wherein:
(a) R 10 is H, and R 11 is OH, OR A , where R A is saturated C 1-4 alkyl;
(b) R 10 and R 11 form a nitrogen-carbon double bond between the nitrogen and carbon atoms to which they are bound; or
(c) R 10 is H and R 11 is SO z M, where z is 2 or 3 and M is a monovalent pharmaceutically acceptable cation, or both M together are a divalent pharmaceutically acceptable cation.
2. A compound according to claim 1 , wherein R 10 and R 11 and form a nitrogen-carbon double bond.
3. A compound selected from the group consisting of:
wherein either
(a) R 10 is carbamate nitrogen protecting group, and R 11 is O-Prot O, wherein Prot O is an oxygen protecting group; or
(b) R 10 is a hemi-aminal nitrogen protecting group and R 11 is an oxo group.
4. A compound according to claim 3 , wherein R 10 is Troc and/or R 11 is OTBS.
5. A compound according to claim 3 , wherein R 11 is oxo and R 10 is SEM.
6. A compound of formula C1:
wherein R 10 and R 11 and form a nitrogen-carbon double bond.
7. A compound of formula C3:
wherein R 10 and R 11 and form a nitrogen-carbon double bond.
8. A compound of formula C4:
wherein R 10 and R 11 and form a nitrogen-carbon double bond.
9. A compound of formula C5:
wherein R 10 and R 11 and form a nitrogen-carbon double bond.
10. A compound which is of formula C6:
wherein R 10 and R 11 and form a nitrogen-carbon double bond.