Method for measuring temperature of biological sample, measuring device, and biosensor system
The concentration measurement method includes: introducing a predetermined amount of the biological sample into the capillary; measuring a temperature of the biological sample by applying a first voltage to the electrode unit when the temperature of the biological sample is measured, the first voltage allowing the temperature measurement to be less affected by increase and reduction in an amount of the analyte contained in the biological sample; measuring the concentration of the analyte contained in the biological sample by applying a second voltage to the electrode unit; measuring an environmental temperature in a surrounding of the biological sample; and correcting the concentration of the measured analyte based on the measured temperature of the biological sample and the measured environmental temperature.
1. A concentration measurement method of measuring a concentration of an analyte contained in a biological sample in a sensor chip including: an electrode unit including a working electrode and a counter electrode, the electrode unit including a reagent containing an electrolyte, and a capillary allowing the biological sample to be introduced therein, the concentration measurement method comprising:
an introduction of introducing a predetermined amount of the biological sample into the capillary;
a temperature measurement of measuring a temperature of the biological sample by applying a first voltage to the electrode unit when the temperature of the biological sample is measured, the first voltage having a potential difference of 1.0 V or greater;
a concentration measurement of measuring the concentration of the analyte contained in the biological sample by applying a second voltage to the electrode unit, the first voltage being greater than the second voltage;
wherein the temperature measurement is executed at least twice in the temperature measurement of measuring a temperature.
2. The concentration measurement method according to claim 1 ,
wherein the temperature measurement of measuring temperature is executed during the concentration measurement of measuring the concentration.
3. The concentration measurement method according to claim 2 , the concentration measurement method further comprising:
a correction of correcting the concentration of the analyte measured in the concentration measurement based on the temperature of the biological sample measured in the temperature measurement.
4. The concentration measurement method according to claim 2 ,
wherein the concentration measurement includes applying the second voltage to a measurement electrode that is separate from the electrode unit, and the temperature measurement is executed independently from the concentration measurement.
5. The concentration measurement method according to claim 4 ,
wherein an order and a timing of the application of the first voltage in the temperature measurement is arbitrarily determined with respect to the application of the second voltage in the concentration measurement.
6. The concentration measurement method according to claim 1 ,
wherein the temperature measurement of measuring temperature is executed immediately after starting the concentration measurement of measuring the concentration and immediately before completing concentration measurement of measuring the concentration.
7. The concentration measurement method according to claim 1 ,
wherein the temperature measurement of measuring temperature is executed before and after the concentration measurement of measuring the concentration.
8. The concentration measurement method according to claim 1 ,
wherein the concentration measurement includes measuring the concentration of the analyte by measuring at least one of concentrations of glucose, hematocrit and reducing substance.
9. The concentration measurement method according to claim 1 ,
wherein the temperature measurement is executed after the concentration measurement is completed.
10. A measuring device for measuring a concentration of an analyte contained in a biological sample, wherein the measuring device is configured to apply a voltage to a sensor chip including an electrode unit including a working electrode and a counter electrode, the electrode unit including a reagent containing an electrolyte, the measuring device comprising;
an insertion section allowing the sensor chip to be loaded therein;
a voltage application section configured to apply a first voltage to the electrode unit of the sensor chip loaded into the insertion section, the first voltage having a potential difference of 1.0 V or greater; and
a temperature measurement section configured to measure a temperature of the biological sample located in the sensor chip based on an output value of the first voltage applied by the voltage application section,
wherein the temperature measurement section is configured to execute a temperature measurement at least twice.
11. The measuring device according to claim 10 ,
wherein the voltage application section is configured to apply a direct-current voltage falling in a voltage range allowing the biological sample to be electrolyzed.
12. The measuring device according to claim 10 , further comprising:
the voltage application section configured to apply a second voltage to the electrode unit; and
an analyte measurement section configured to measure a concentration of the analyte contained in the biological sample based on an output value of the second voltage applied by the voltage application section.
13. The measuring device according to claim 12 ,
wherein the analyte measurement section is configured to measure the concentration of the analyte by measuring at least one of concentrations of glucose, hematocrit and reducing substance.
14. The measuring device according to claim 12 ,
wherein the first voltage applied by the voltage application section in the temperature measurement is greater than the second voltage applied by the voltage application section in the concentration measurement.