NOVEL ACTIVE INGREDIENT IN CICATRIZATION AND USE THEREOF
The present invention relates to the use of a known compound as an agent for promoting and/or accelerating fibroblast proliferation and/or differentiation and, consequently, cicatrization. This compound is a copolymer of a 2-methyl-2-[(1-oxo-2-propenyl)amino]-1-propanesulphonic acid salt and of propenoic acid 2-hydroxyethyl ester. It may be used alone or in combination with other active substances for inducing or accelerating cicatrization. This compound, alone or in combination with another active substance, may be administered directly on the wound and the surrounding area or the mucous membranes, by topical application. It may also be used ex vivo, in particular for generating cells for skin grafts.
1 - 12 . (canceled)
13 . A method for promoting and/or accelerating fibroblast proliferation in vivo or ex vivo, comprising: providing a composition comprising an effective amount of a copolymer of a salt of 2-methyl-2-[(1-oxo-2-propenyl)amino]-1-propanesulfonic acid and of 2-hydroxyethylpropenoate ester.
14 . The method as claimed in claim 13 , wherein said composition is administered to promote healing.
15 . The method as claimed in claim 13 , wherein said copolymer is combined with one or more active substances.
16 . The method as claimed in claim 13 , wherein said copolymer is combined with a sulfated saccharide.
17 . The method as claimed in claim 13 , wherein said salt of 2-methyl-2-[(1-oxo-2-propenyl)amino]-1-propane-sulfonic acid is a sodium salt.
18 . The method as claimed in claim 15 , wherein said copolymer is combined with a sulfated saccharide.
19 . The method as claimed in claim 13 , wherein said copolymer is combined with potassium sucrose octasulfate.