METHOD FOR IMPROVING HEALTH OUTCOMES
Method of using an antiseptic and pH modulating solution provides improved health outcomes in part by decolonizing surfaces, animate and inanimate, and improving tissue function and stress response, particularly the barrier properties and antimicrobial properties of tissues, especially skin and muscles, whether damaged or intact and at risk of damage. The method includes initial application followed by continued topical application on a periodic basis until the damaged area is restored or the risk of injury has passed, followed by continued maintenance application for a period of time thereafter. The method of using the solution is believed to restore and improve the functioning of tissues that naturally interrupt pathogenic mechanisms of disease in addition to providing antimicrobial support. The method can be adapted to improve a plurality of health or consumer care outcomes, from preventing or substantially reducing rates of hospital acquired infections to improving muscle performance and recovery, among others.
1 . A method for enhancing the efficacy of topical antiseptic formulations having broad-spectrum antimicrobial activity, the formulation comprising fast-acting antimicrobial compounds for topical application and preservatives having antimicrobial activity for the purpose of prolonging shelf life by inhibiting microbial growth in the formulation, the method comprising treating the formulation with a sterilization technique selected from the group consisting of subjecting the formulation to gamma radiation, e-beam radiation, dry heat, ethylene oxide gas, steam, hydrogen peroxide gas plasma, ozone, chlorine dioxide gas, ethylene oxide in-a-bag, high intensity light, microwave radiation, sound waves, ultraviolet light, vaporized chemical sterilizing systems, and combinations thereof to achieve a log reduction in colony forming units of at least about 10 −2 , thereby retaining the antimicrobial activity of the preservatives and the fast-acting compounds, whereby the antimicrobial activity of the preservatives enhances the broad-spectrum topical antiseptic efficacy of the formulation.
2 . The method of claim 1 wherein the step of treating the formulation with a sterilization technique sterilizes the formulation, achieving a sterility assurance level of at least about 10 −6 .
3 . The method of claim 1 wherein the step of treating the formulation with a sterilization technique comprises subjecting the formulation to a treatment dose of gamma radiation.
4 . The method of claim 3 wherein the treatment dose is from 4 to less than 35 kGy of gamma radiation.
5 . A method for enhancing the efficacy of topical antiseptic formulations having broad-spectrum antimicrobial activity, the formulation comprising fast-acting antimicrobial compounds for topical application and preservatives having antimicrobial activity for the purpose of prolonging shelf life by inhibiting microbial growth in the formulation, the method comprising treating the formulation with a radiation treatment dose to achieve a log reduction in colony forming units of at least about 10 −2 , thereby retaining the antimicrobial activity of the preservatives and the fast-acting compounds, whereby the antimicrobial activity of the preservatives enhances the broad-spectrum topical antiseptic efficacy of the formulation.
6 . The method of claim 5 wherein the step of treating the formulation with a radiation treatment dose comprises subjecting the formulation to less than a sterilization dose, wherein the formulation is not a sterilized formulation.
7 . The method of claim 6 wherein the step of treating the formulation with a radiation treatment dose comprises treating the formulation with gamma radiation at a dose of from 4 to 7 kGy.
8 . The method of claim 5 wherein the step of treating the formulation with a radiation treatment dose comprises treating the formulation with gamma radiation at a dose of less than about 35 kGy.
9 . The method of claim 8 wherein the step of treating the formulation with a radiation treatment dose achieves a log reduction in colony forming units of from about 10 −6 to 10 −2 .
10 . A skin cleanser with preservatives, the skin cleanser exhibiting broad-spectrum antimicrobial activity suitable for use as a topical antiseptic, the skin cleanser comprising fast-acting antimicrobial compounds for topical application and preservatives having antimicrobial activity for the purpose of prolonging shelf life by inhibiting microbial growth in the skin cleanser, the skin cleanser treated with a sterilization technique selected from the group consisting of subjecting the skin cleanser to gamma radiation, e-beam radiation, dry heat, ethylene oxide gas, steam, hydrogen peroxide gas plasma, ozone, chlorine dioxide gas, ethylene oxide in-a-bag, high intensity light, microwave radiation, sound waves, ultraviolet light, vaporized chemical sterilizing systems, and combinations thereof to achieve a log reduction in colony forming units of at least about 10 −2 , thereby retaining the antimicrobial activity of the preservatives and the fast-acting compounds, whereby the antimicrobial activity of the preservatives enhances the broad-spectrum topical antiseptic efficacy of the skin cleanser.
11 . The skin cleanser of claim 10 wherein said skin cleanser is treated with a sterilization technique, and is not sterile, the log reduction in colony forming units being less than about 10 −6 .
12 . The skin cleanser of claim 10 wherein the skin cleanser is treated with gamma radiation at a dose of from 4 to 7 kGy.
13 . The skin cleanser treated with a sterilization technique as recited in claim 10 having a log reduction in colony forming units of form 10 −2 to 10 −6 .
14 . The skin cleanser of claim 10 wherein the preservatives are selected from the group consisting of methyl paraben, propyl paraben, and EDTA.
15 . The skin cleanser of claim 10 wherein the fast-acting antimicrobial compounds are selected from the group consisting of grapefruit extract and colloidal silver.