Peptides and their use in the treatment of hair
View Patent ↗Peptides, topical compositions, and methods of improving health and/or appearance of human integuments, such as keratinous surfaces and fibers are provided. The peptides have from 3-12 amino acid residues and comprise the sequence YNT (SEQ ID NO: 1) or PVG (SEQ ID NO: 2).
1. A topical composition for improving the health and/or appearance of hair, thickening hair, and/or promoting hair growth comprising
an active agent selected from YNT (SEQ ID NO: 1), K-Ava-YNTK (SEQ ID NO: 3), or palmitoyl-YNT, and
a physiologically acceptable vehicle,
wherein the active agent is present in an amount from 0.0001% to 10% by weight of the composition.
2. The topical composition according to claim 1 , wherein said active agent consists of said peptide optionally functionalized with a C 2-24 hydrocarbon.
3. The topical composition according to claim 2 , wherein said active agent is palmitoyl-YNT.
4. The topical composition according to claim 1 , wherein said active agent is K-Ava-YNTK (SEQ ID NO: 3).
5. The topical composition of claim 1 , wherein the active agent is present in an amount from 0.001% to 1% by weight of the composition.
6. The topical composition of claim 1 , wherein said physiologically acceptable vehicle comprises a water-in-oil, oil-in-water, silicone-in-water, or water-in-silicone emulsion.
7. The topical composition of claim 1 , wherein said composition is in the form of shampoo, conditioner, hair gel, mousse, tonic, or lotion.
8. The topical composition of claim 1 , wherein said composition further comprises one or more ingredients selected from the group consisting of creatine, a botanical extract from Pouzolzia pentandra , N-biotinyl-gly-his-lys, hydrolyzed wheat protein, saw palmetto extract, Emblica officianalis extract, and beta-glycyrrhetic acid.
9. The topical composition of claim 1 , wherein said active agent is YNT (SEQ ID NO: 1), or K-Ava-YNTK (SEQ ID NO: 3).
10. The topical composition of claim 1 , wherein said active agent is YNT (SEQ ID NO: 1).
11. A method for strengthening, thickening, and/or promoting growth of human keratin fibers, wherein the method comprises topically applying the topical composition according to claim 1 to the skin in the area of keratin fiber follicles.
12. The method according to claim 11 , wherein said active agent consists of said peptide optionally functionalized with a C 2-24 hydrocarbon to improve lipophilicity.
13. The method according to claim 11 , wherein said active agent is palmitoyl-YNT.
14. The method according to claim 11 , wherein said active agent is K-Ava-YNTK (SEQ ID NO: 3).
15. The method according to claim 11 , wherein said composition is applied at least once daily for at least four weeks.