Heterocyclic compounds and uses thereof
The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.
1. A method for treating a proliferative disorder comprising administering to a patient in need thereof a compound represented by structural formula I-a
or a pharmaceutically acceptable salt thereof, wherein:
n is 0, 1, or 2;
m is 0, 1, or 2, wherein m and n are not simultaneously 0;
W is —O— or —NH—;
R 1 is —OR;
each R is independently C 1-4 alkyl or C 1-4 fluoroalkyl;
R 2 is —CF 3 , Cl, or Br;
G is —NR 3 — or —S(O) 2 —; and
R 3 is —C(O)—R, —C(O)OR, —C(O)NHR, —SO 2 —R, —SO 2 NH 2 , —C(O)—C 1-4 alkylene-OH or —SO 2 —C 1-4 alkylene-OH; and
wherein the proliferative disorder is a cancer.
2. The method of claim 1 , wherein the cancer is selected from: breast cancer, glioblastoma, lung cancer, cancer of the head and neck, colorectal cancer, and bladder cancer.
3. The method of claim 2 , wherein the cancer is a lung cancer.
4. The method of claim 3 , wherein the lung cancer is non-small cell lung cancer.
5. The method of claim 1 , wherein the compound is represented by structural formula III-a:
or a pharmaceutically acceptable salt thereof.
6. The method of claim 5 , wherein W is —NH—.
7. The method of claim 5 , wherein R 2 is —CF 3 .
8. The method of claim 5 , wherein:
R 2 is —CF 3 or Cl; and
R 3 is —C(O)CH 3 or —SO 2 CH 3 .
9. The method of claim 6 , wherein:
R 2 is —CF 3 or Cl; and
R 3 is —C(O)CH 3 .
10. The method of claim 6 , wherein:
R 2 is —CF 3 or Cl; and
R 3 is —SO 2 CH 3 .
11. The method according to claim 5 , wherein:
W is —O—;
R 2 is —CF 3 or Cl; and
R 3 is —C(O)CH 3 .
12. The method of claim 5 , wherein:
W is —O—;
R 2 is —CF 3 or Cl; and
R 3 is —SO 2 CH 3 .
13. The method of claim 1 , wherein the compound is selected from:
or a pharmaceutically acceptable salt thereof.
14. The method of claim 1 , wherein the compound is:
or a pharmaceutically acceptable salt thereof.