Nasal cannula for continuous and simultaneous delivery of aerosolized medicament and high flow therapy
Systems, devices, and methods are disclosed for nasal cannulas allowing simultaneous flow of humidified breathing gas and aerosolized medicament for use in respiratory therapy. Utilizing separate flow paths and separate cannula outlets for the heated and humidified breathing gas and for the aerosolized medicament, these systems, methods, and devices reduce condensation of the aerosolized medicament by delaying mixing of the flow of aerosolized medicament and the flow of heated and humidified breathing gas until the flows exit the cannula.
1. A nasal cannula for delivering humidified breathing gas and nebulized medication, the nasal cannula comprising:
a first prong having a first outlet, a longitudinal axis, and a first length along the longitudinal axis;
a second prong having a second outlet;
a third prong having a third length, disposed on an outer surface of the first prong, and comprising a first medicament outlet configured to pass aerosolized medicament substantially parallel to the longitudinal axis, the third prong extending alongside the first prong and sharing a common wall with the first prong such that breathing gas and medicament flows are separated by the common wall, wherein the third length is less than the first length of the first prong;
a first tube having a first inlet for receiving breathing gas, the first tube being in fluid communication with the first and second prongs; and
a second tube having a second inlet for receiving the aerosolized medicament, the second tube being in fluid communication with the first medicament outlet;
wherein the first tube is not in fluid communication with the second tube along a second length of the second tube; and
wherein the cannula is configured such that during operation a velocity of the humidified breathing gas exiting the first outlet is greater than a velocity of the aerosolized medicament exiting the first medicament outlet.
2. The nasal cannula of claim 1 , wherein the first medicament outlet is offset from the first outlet along the longitudinal axis.
3. The nasal cannula of claim 2 , wherein the first medicament outlet is upstream from the first outlet with respect to a direction of breathing gas flow through the first outlet.
4. The nasal cannula of claim 3 , wherein the first medicament outlet is offset by more than 1 mm and less than 3 cm along the longitudinal axis.
5. The nasal cannula of claim 4 , wherein the first medicament outlet is configured to mix a first flow of the aerosolized medicament with the breathing gas flow through the first outlet downstream from the first outlet.
6. The nasal cannula of claim 1 , wherein the third prong is integrally formed on the first prong along the common wall.
7. The nasal cannula of claim 1 , further comprising a second medicament outlet disposed adjacent to the second prong and arranged to pass the aerosolized medicament substantially parallel to the longitudinal axis.
8. The nasal cannula of claim 1 , wherein the first prong and the second prong extend from a facepiece, the facepiece being substantially orthogonal to the longitudinal axis and having a first end and a second end opposite the first end.
9. The nasal cannula of claim 8 , wherein the first tube is coupled to the first end and the second tube is coupled to the second end.
10. The nasal cannula of claim 8 , wherein the medicament outlet is disposed on the facepiece between the first prong and the second prong.
11. The nasal cannula of claim 1 , wherein the second tube has an internal diameter of 5 mm or more.
12. The nasal cannula of claim 11 , wherein the second tube has an internal diameter of 10 mm or more.
13. The nasal cannula of claim 1 , wherein the second length of the second tube is 20 cm or more.
14. The nasal cannula of claim 1 , wherein the second tube has an internal volume of 20 cm 3 or greater.
15. The nasal cannula of claim 1 , wherein the second tube has an internal volume of 70 cm 3 or greater.
16. The nasal cannula of claim 1 , wherein the first outlet has a first cross-sectional area and the first medicament outlet has a second cross-sectional area, wherein the second cross-sectional area is less the first cross-sectional area.
17. The nasal cannula of claim 16 , wherein the second cross-sectional area is one third of the first cross-sectional area or greater.
18. The nasal cannula of claim 1 , wherein a flow resistance from the second inlet to the first medicament outlet is less than 1 psi at a flow rate of 1 LPM.
19. The nasal cannula of claim 1 , wherein the third prong is arranged to be detachably affixed to either the first prong or the second prong.
20. The nasal cannula of claim 19 , wherein the first prong comprises a first connection point and the second prong comprises a second connection point, such that the third prong is arranged to be detachably affixed to either the first prong via the first connection point or the second prong via the second connection point.
21. The nasal cannula of claim 20 , wherein the first connection point is located on a dorsal side of the first prong, and the second connection point is located on a dorsal side of the second prong.
22. The nasal cannula of claim 1 , wherein the first medicament outlet comprises a directional element arranged to extend beyond a lip of the first medicament outlet to direct the aerosolized medicament towards a slipstream of breathing gas.
23. A method for delivering humidified breathing gas and nebulized medication, the method comprising:
passing heated and humidified breathing gas through a first conduit to a first outlet and a second outlet of a nasal cannula, the first conduit having a first length; and
passing an aerosolized medicament through a second conduit to a third outlet, the second conduit having a second length of 10 cm or greater, wherein the third outlet is disposed on an outer surface of the first outlet and is configured to pass aerosolized medicament substantially parallel to the longitudinal axis, the third outlet extending alongside the first outlet and sharing a common wall with the first outlet such that breathing gas and medicament flows are separated by the common wall, the second length being less than the first length;
wherein, the heated and humidified breathing gas mixes with the aerosolized medicament after exiting the nasal cannula; and
wherein a velocity of the humidified breathing gas exiting the first outlet is greater than a velocity of the aerosolized medicament exiting the third outlet.
24. The method of claim 23 , wherein the second conduit is not in fluid communication with the first conduit along the first length of the first conduit.
25. The method of claim 24 , wherein the third outlet is offset from the first outlet along a longitudinal axis of the first outlet.
26. The method of claim 25 , wherein the aerosolized medicament is entrained by the flow of heated and humidified breathing gas out of the first outlet.
27. The method of claim 23 , wherein the heated and humidified breathing gas is passed through the first conduit at a rate of 8 LPM or greater.
28. The method of claim 27 , wherein the aerosolized medicament is passed through the second conduit at a rate of 2 LPM or less.
29. The method of claim 23 , wherein an inlet of the first conduit is adjacent to an inlet of the second conduit.
30. A respiratory therapy system for delivering humidified breathing gas and nebulized medication, the system comprising:
a nasal cannula including:
a first prong having a first outlet and a longitudinal axis;
a second prong having a second outlet;
a third prong having a third length, disposed on an outer surface of the first prong, and comprising a first medicament outlet configured to pass aerosolized medicament substantially parallel to the longitudinal axis, the third prong extending alongside the first prong and sharing a common wall with the first prong such that breathing gas and medicament flows are separated by the common wall, wherein the third length is less than the first length of the first prong;
a first tube in fluid communication with the first and second prongs; and
a second tube having a second length, wherein the first tube is not in fluid communication with the second tube along a length of the first tube;
a nebulizer in fluid communication with the first medicament outlet through the second tube; and
wherein the respiratory therapy system is configured such that during operation a velocity of the humidified breathing gas exiting the first outlet is greater than a velocity of the aerosolized medicament exiting the first medicament outlet.
31. The system of claim 30 , further comprising a source of pressurized driving gas in fluid communication with the second tube, wherein the source of pressurized driving gas supplies gas that carries the aerosolized medicament to the patient.
32. The system of claim 30 , further comprising a source of heated and humidified breathing gas in fluid communication with the first and second prongs.
33. The system of claim 30 , wherein the first medicament outlet is offset from the first outlet along the longitudinal axis.
34. The system of claim 30 , wherein the first medicament outlet is configured to mix a first flow of the aerosolized medicament with a second flow of breathing gas downstream from the first outlet.
35. The system of claim 30 , further comprising a second medicament outlet disposed adjacent to the second prong and arranged to pass the aerosolized medicament substantially parallel to the longitudinal axis.
36. The system of claim 30 , wherein the first prong and the second prong extend from a facepiece, the facepiece being substantially orthogonal to the longitudinal axis and having a first end and a second end opposite the first end.
37. The system of claim 36 , wherein the first tube is coupled to the first end and the second tube is coupled to the second end.
38. The system of claim 30 , wherein the second tube has an internal diameter of 5 mm or more.
39. The system of claim 30 , wherein the second length of the second tube is 2 feet or more.
40. The system of claim 30 , wherein the second tube has an internal volume of 20 cm 3 or greater.