IP Library › Patent Application 15200993
Patent Application
App. No. 15/200,993

Transdiscal Administration Of Specific Inhibitors Of Pro-Inflammatory Cytokines

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Quick Facts
Patent No.
US None
App. No.
15/200,993
Abstract

The present invention relates to injecting a high specificity cytokine antagonist into a diseased intervertebral disc.

Claims (6)

1 - 20 . (canceled)

21 . A method of treating a degenerative disease in an orthopedic joint, comprising administering into cartilage of the joint a formulation comprising viable, concentrated, cultured, allogenic, mesenchymal progenitor cells, wherein the cells were obtained from bone marrow aspirate by immunoabsorption with antibodies selected to recognize alkaline phosphatase cell surface antigen.

22 . The method of claim 21 , wherein the antibodies are selected to further recognize STRO-1 cell surface antigen.

23 . The method of claim 22 , wherein the mesenchymal progenitor cells co-express STRO-1 cell surface antigen and alkaline phosphatase cell surface antigen.

24 . The method of claim 23 , wherein the formulation further comprises hyaluronic acid.

25 . The method of claim 24 , wherein the formulation consists essentially of the mesenchymal progenitor cells and hyaluronic acid.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 11, 2017
From: ATTAWIA, MOHAMED; DIMAURO, THOMAS M.; SERHAN, HASSAN; KADIYALA, SUDHAKAR; URBAHNS, DAVID; BRUDER, SCOTT
To: DEPUY SPINE, INC.
Reel/Frame 043268/0320 →