METHODS FOR DIAGNOSING, PROGNOSING, OR THERANOSING A CONDITION USING RARE CELLS
Described herein are methods for diagnosing, prognosing, or theranosing a condition using rare cells.
1 .- 10 . (canceled)
11 . A method for diagnosing, theranosing, or prognosing a condition in a patient comprising:
performing one or more nucleic acid analysis on a first sample obtained from said patient; enumerating one or more rare cells in a second sample from said patient; and diagnosing, theranosing, or prognosing the condition in said patient based on said enumerating one or more rare cells and said performing one or more nucleic acid analysis.
12 . The method of claim 11 , wherein the first sample is a biopsy sample, the second sample is a blood sample, or the first and second sample are the same sample.
13 . The method of claim 11 , wherein performing one or more nucleic acid analysis comprises SNP analysis, mRNA analysis, or sequencing.
14 . The method of claim 11 , wherein the one or more rare cells comprise circulating tumor cells.
15 . The method of claim 11 , wherein the one or more rare cells are enriched using a microfluidic device.
16 . The method of claim 15 , wherein the microfluidic device comprises one or more binding moieties and/or an array of obstacles.
17 . The method of claim 16 , wherein the one or more binding moieties comprise anti-EpCAM.
18 . The method of claim 11 , further comprising subjecting said patient to one or more therapeutic treatments; repeating said performing one or more nucleic acid analysis and said enumerating one or more rare cells; and diagnosing, prognosing or theranosing the condition in the patient.
19 .- 37 . (canceled)