Compounds useful as modulators of TRPM8
The present invention includes compounds useful as modulators of TRPM8, such as compounds of Formula (I) and the subgenus and species thereof; personal products containing those compounds; and the use of those compounds and the personal products, particularly the use of increasing or inducing chemesthetic sensations, such as cooling or cold sensations.
1. A composition comprising a compound having structural Formula (II):
or a salt or solvate thereof;
wherein Ar is optionally substituted aryl, optionally substituted carbocyclyl, or optionally substituted pyrrolyl, furanyl, thienyl, pyrazolyl, triazolyl, oxazolyl, thiazolyl, isoxazolyl, isothiazolyl, pyridyl, pyrimidyl, or triazinyl;
X 1 -X 2 is O—CR 2a R 2b , or CR 5 ═CR 6 ;
R 2a , R 2b , R 5 , and R 6 are independently hydrogen or lower alkyl;
Y is oxygen or sulfur;
Z is nitrogen or CR;
n is 0, 1, or 2;
R is hydrogen or lower alkyl;
R 1 is an optionally substituted group selected from the group consisting of pyrrolyl, furanyl, thienyl, and pyrazolyl; and
each R 2 is independently optionally substituted C 1 -C 6 alkyl, optionally substituted C 2 -C 6 alkenyl, C 1 -C 6 alkoxy, hydroxyl, halo, nitro, or cyano,
wherein each optional substituent is selected from the group consisting of C 1 -C 6 alkyl, alkenyl, C 1 -C 6 alkoxy, hydroxyl, halo, nitro, or cyano; or two substituents, together with the atoms to which they are attached, form an optionally substituted carbocyclyl or heterocyclyl containing one or more heteroatom(s) selected from nitrogen, oxygen, and sulfur; and
a carrier.
2. The composition of claim 1 , wherein Y is sulfur.
3. The composition of claim 1 , Z is nitrogen or CR.
4. The composition of claim 1 , wherein n is 0.
5. The composition of claim 1 , wherein R 1 is an optionally substituted group selected from the group consisting of furanyl, thienyl, and pyrazolyl.
6. A composition comprising a compound, wherein the compound selected from the group consisting of:
or a salt or solvate thereof, and
a carrier.
7. A composition comprising a compound, wherein the compound selected from the group consisting of:
or a salt or solvate thereof, and
a carrier.
8. The composition of claim 1 , wherein the compound selected from the group consisting of:
or a salt or solvate thereof.
9. The composition of claim 1 , wherein the compound selected from the group consisting of:
or a salt or solvate thereof.
10. The composition of claim 1 , wherein the compound selected from the group consisting of:
or a salt or solvate thereof.
11. The composition of claim 10 , wherein the composition is an ingestible composition or personal care composition.
12. The composition of claim 11 , wherein the ingestible composition is a food or beverage.
13. The composition of claim 1 , wherein the composition is in form of a solid, semi-solid, plaster, solution, suspension, lotion, cream, foam, gel, paste, emulsion, or a combination thereof.
14. The composition of claim 1 , wherein the compound in the composition is in a concentration ranging from about 0.0001 ppm to 100,000 ppm.
15. The composition of claim 1 , wherein the compound in the composition is in a concentration ranging from about 1 ppm to 500 ppm.
16. The composition of claim 1 , which is a component of a textile product or a packaging material.
17. The composition of claim 1 , wherein the compound is:
or a salt or solvate thereof.