SOLID DRESSING FOR TREATING WOUNDED TISSUE
Disclosed are solid dressings for treated wounded tissue in mammalian patients, such as a human, comprising a haemostatic layer consisting essentially of fibrinogen and a fibrinogen activator, wherein the fibrinogen is present in an amount between 3.0 mg/cm 2 of the wound facing surface of the dressing and 13.0 mg/cm 2 of the wound facing surface of the dressing. Also disclosed are methods for treating wounded tissue.
1 . A solid dressing for treating wounded tissue in a mammal comprising at least one haemostatic layer consisting essentially of fibrinogen and a solvent consisting of water and a fibrinogen activator wherein said haemostatic layer is substantially homogeneous, wherein said fibrinogen is present in an amount about 13.0 mg/cm 2 of the wound facing surface of said dressing, and wherein the moisture content of said solid dressing is from 6% to 44%.
2 . The solid dressing of claim 1 , further comprising at least one support layer.
3 . The solid dressing of claim 2 , wherein said support layer comprises a backing material.
4 . The solid dressing of claim 2 , wherein said support layer comprises an internal support material.
5 . The solid dressing of claim 2 ; wherein said support layer comprises a resorbable material.
6 . The solid dressing of claim 2 , wherein said support layer comprises a non resorbable material.
7 . (canceled)
8 . The solid dressing of claim 3 , further comprising at least physiologically acceptable adhesive between said haemostatic layer and said backing layer.
9 - 11 . (canceled)
12 . The solid dressing of claim 1 , wherein said haemostatic layer also contains a fibrin crosslinker and/or a source of calcium ions.
13 . The solid dressing of claim 1 , wherein said haemostatic layer also contains one or more of the following: at least one filler, at least one solubilizing agent, at least one foaming agent and at least one release agent.
14 - 21 . (canceled)
22 . The solid dressing of claim 1 , wherein said haemostatic layer is composed of a plurality of particles, each of said particles consisting essentially of fibrinogen and thrombin.
23 . The solid dressing of claim 22 , wherein said haemostatic layer further contains at least one binding agent in an amount effective to improve the adherence of said particles to one another.
24 . (canceled)
25 . The solid dressing of claim 1 , wherein said haemostatic layer is a monolith.
26 . The solid dressing of claim 1 , wherein said haemostatic layer has been lyophilized.
27 - 37 . (canceled)
38 . The solid dressing of claim 1 , wherein said fibrinogen activator is present in an amount between 2.50 Units/mg of fibrinogen component and 0.025 Units/mg of the fibrinogen.
39 . (canceled)
40 . A method of treating wounded tissue in a mammal, comprising placing a solid dressing of claim 1 to said wounded tissue and applying sufficient pressure to said dressing for a sufficient time for enough fibrin to form to reduce the loss of blood and/or other fluid from said wounded tissue.
41 . The solid dressing of claim 1 , wherein said moisture content is at least 28%.