IP Library Granted Patent US 10,413,902
Granted Patent B2
US 10,413,902 · App. 15/210,689 · Granted Sep 17, 2019

Apparatus for sample separation and collection

Inventors: Rafael Bru Gilbert (Barcelona, ES); Mathias Kuphal (Barcelona, ES); Jordi Carrera Fabra (Barcelona, ES); Ricard Martin Blanco (Barcelona, ES); Francisco Javier Ramírez (Barcelona, ES)
Assignee: STAT-DIAGNOSTICA & INNOVATION, S.L.
B01L3/502753B04B5/04B04B7/02B04B7/06B04B7/08B04B15/08B01L3/502715B01L2200/027B01L2200/0684B01L2300/0803B01L2300/0864B01L2400/0409B04B2007/025
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Quick Facts
Patent No.
US 10,413,902
App. No.
15/210,689
Granted
Sep 17, 2019
Kind
B2
Abstract

A centrifuge device and method for use are presented. The centrifuge device includes a housing, a chamber, a channel, and a cover. The housing includes a first port and a vent opening and is designed to rotate about an axis passing through a center of the housing. The chamber is defined within the housing and is coupled to the first port. A first portion of the chamber has a width that tapers between a first width at a first position and a second width at a second position within the chamber, the first width being greater than the second width. The channel is coupled to the second position of the chamber and arranged such that a path exists for gas to travel from the channel to the vent opening. The cover provides a wall that seals the chamber.

Claims (27)

1. A centrifuge device, comprising:

a housing having a first port and a vent opening, wherein the housing is configured to rotate about an axis passing through a center of the housing;

a chamber defined by the housing and a cover, wherein the chamber is coupled to the first port, wherein a first portion of the chamber has a width that tapers between a first width at a first position and a second width at a second position within the chamber, the first width being greater than the second width;

a channel coupled to the second position of the chamber and arranged such that a path exists for gas to travel from the channel to the vent opening; and

the cover having a second port and configured to provide a wall to seal the chamber.

2. The centrifuge device of claim 1 , further comprising a second chamber coupled between the channel and the vent opening.

3. The centrifuge device of claim 1 , wherein the second port has a diameter between 100 and 500 micrometers.

4. The centrifuge device of claim 1 , wherein the second port has a diameter between 150 and 350 micrometers.

5. The centrifuge device of claim 1 , wherein the cover includes a coupling structure configured to couple the chamber with an extraction device.

6. The centrifuge device of claim 1 , wherein the chamber contains a fluid volume of about 250 microliters.

7. The centrifuge device of claim 1 , wherein the housing has a cylindrical shape.

8. The centrifuge device of claim 7 , wherein a diameter of the cylindrical housing is less than 20 mm.

9. The centrifuge device of claim 7 , wherein the first portion of the chamber extends along a circumference of the housing, and a second portion of the chamber extends radially from the axis passing through the center of the housing.

10. The centrifuge device of claim 9 , wherein the second port is positioned substantially above the second portion of the chamber.

11. The centrifuge device of claim 9 , wherein the second portion of the chamber has a hydraulic diameter less than 5 millimeters.

12. The centrifuge device of claim 1 , wherein the housing includes a hinged portion, wherein the hinged portion is configured to swing open to expose the first port.

13. The centrifuge device of claim 12 , wherein the hinged portion includes a raised structure configured to seal the first port when the hinged portion is closed.

14. The centrifuge device of claim 1 , further comprising a sample indicator configured to indicate when the chamber has been filled to a maximum level.

15. The centrifuge device of claim 1 , wherein a shortest distance between the channel and the axis of rotation is shorter than a distance between any point of the chamber and the axis of rotation.

16. A system comprising:

a centrifuge device, comprising:

a housing having a first port and a vent opening, wherein the housing is configured to rotate about an axis passing through a center of the housing,

a chamber defined by the housing and a cover, wherein the chamber is coupled to the first port, wherein a first portion of the chamber has a width that tapers between a first width at a first position and a second width at a second position within the chamber, the first width being greater than the second width,

a channel coupled to the second position of the chamber and arranged such that a path exists for gas to travel from the channel to the vent opening, and

the cover having a second port and configured to provide a wall to seal the chamber;

an actuator coupled to the housing and configured to rotate the housing about the axis; and

an extraction device coupled to the cover and configured to extract a sample within the chamber through the second port.

Assignments (3)
CHANGE OF NAME Recorded Nov 30, 2023
From: STAT-DIAGNOSTICA & INNOVATION, S.L.
To: STAT-DX LIFE S.L.
Reel/Frame 066335/0871 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 30, 2023
From: STAT-DX LIFE S.L.
To: QIAGEN GMBH
Reel/Frame 065729/0209 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 7, 2018
From: BRU GIBERT, RAFAEL; KUPHAL, MATHIAS; CARRERA FABRA, JORDI; BLANCO, RICARD MARTIN; RAMÍREZ, FRANCISCO JAVIER
To: STAT-DIAGNOSTICA & INNOVATION, S.L.
Reel/Frame 045132/0806 →
Continuity (2)
Provisional Application 62193954 · Jul 17, 2015
Related Publication 20170014823A1 · Jan 19, 2017