Platelet-Derived Growth Factor Compositions and Methods of Use Thereof

1 - 78 . (canceled)

79 . An implant material comprising a porous calcium phosphate having incorporated therein a solution comprising a comprising platelet derived growth factor (PDGF) at a concentration in a range of about 0.1 mg/mL to about 1.0 mg/mL in a buffer, wherein the calcium phosphate has interconnected pores, a porosity greater than 40%, and comprises particles in a range of about 100 microns to about 5000 microns in size, and

wherein the calcium phosphate is selected from the group consisting of tricalcium phosphate, hydroxyapatite, amorphous calcium phosphate, calcium metaphosphate, dicalcium phosphate dihydrate, heptacalcium phosphate, calcium pyrophosphate dihydrate, calcium pyrophosphate, and octacalcium phosphate.

80 . The implant material of claim 79 , wherein the PDGF is recombinant PDGF.

81 . The implant material of claim 79 , wherein the PDGF is recombinant PDGF-BB.

82 . The implant material of claim 79 , wherein the solution comprises PDGF at a concentration of about 0.3 mg/mL in a buffer.

83 . The implant material of claim 79 , wherein the solution comprises PDGF at a concentration in a range of about 0.25 mg/mL to about 0.5 mg/mL in a buffer.

84 . The implant material of claim 79 , wherein the solution comprises PDGF at a concentration in a range of about 0.2 mg/mL to about 0.75 mg/mL in a buffer.

85 . The implant material of claim 79 , wherein the calcium phosphate comprises particles in a range of about 100 microns to about 3000 microns in size.

86 . The implant material of claim 79 , wherein the calcium phosphate comprises particles in a range of about 250 microns to about 1000 microns in size.

87 . The implant material of claim 79 , wherein the implant material is resorbable such that at least 80% of the calcium phosphate is resorbed within one year of being implanted.

88 . The implant material of claim 79 , wherein the incorporated solution is adsorbed into or absorbed by the calcium phosphate.

89 . The implant material of claim 79 , wherein the calcium phosphate is capable of absorbing an amount of the solution comprising PDGF that is equal to at least about 25% of the calcium phosphate's own weight.

90 . The implant material of claim 79 , wherein the calcium phosphate is capable of absorbing an amount of the solution comprising PDGF that is equal to at least about 50% of the calcium phosphate's own weight.

91 . The implant material of claim 79 , wherein the calcium phosphate is capable of absorbing an amount of the solution comprising PDGF that is equal to at least about 200% of the calcium phosphate's own weight.

92 . The implant material of claim 79 , wherein the calcium phosphate is capable of absorbing an amount of the solution comprising PDGF that is equal to at least about 300% of the calcium phosphate's own weight.

93 . The implant material of claim 79 , wherein the calcium phosphate is poorly crystalline hydroxyapatite.

94 . An implant material comprising collagen and a porous calcium phosphate having incorporated therein a solution comprising platelet derived growth factor (PDGF) at a concentration in a range of about 0.1 mg/mL to about 1.0 mg/mL in a buffer, wherein the calcium phosphate has interconnected pores, a porosity greater than 40%, and comprises particles in a range of about 100 microns to about 5000 microns in size, and

wherein the calcium phosphate is selected from the group consisting of tricalcium phosphate, hydroxyapatite, amorphous calcium phosphate, calcium metaphosphate, dicalcium phosphate dihydrate, heptacalcium phosphate, calcium pyrophosphate dihydrate, calcium pyrophosphate, and octacalcium phosphate.

95 . The implant material of claim 94 , wherein the PDGF is recombinant PDGF.

96 . The implant material of claim 94 , wherein the PDGF is recombinant PDGF-BB.

97 . The implant material of claim 94 , wherein the calcium phosphate comprises particles in a range of about 100 microns to about 3000 microns in size.

98 . The implant material of claim 94 , wherein the calcium phosphate comprises particles in a range of about 250 microns to about 1000 microns in size.

99 . The implant material of claim 94 , wherein the solution comprises PDGF at a concentration in a range of about 0.25 mg/mL to about 0.5 mg/mL in a buffer.

100 . The implant material of claim 94 , wherein the solution comprises PDGF at a concentration in a range of about 0.2 mg/mL to about 0.75 mg/mL in a buffer.

101 . The implant material of claim 94 , wherein the solution comprises PDGF at a concentration of about 0.3 mg/mL in a buffer.

102 . The implant material of claim 94 , wherein the incorporated solution is adsorbed or absorbed to the calcium phosphate.

103 . The implant material of claim 94 , wherein the calcium phosphate is capable of absorbing an amount of the solution comprising PDGF that is equal to at least about 25% of the calcium phosphate's own weight.

104 . The implant material of claim 94 , wherein the calcium phosphate is capable of absorbing an amount of the solution comprising PDGF that is equal to at least about 50% of the calcium phosphate's own weight.

105 . The implant material of claim 94 , wherein the calcium phosphate is capable of absorbing an amount of the solution comprising PDGF that is equal to at least about 200% of the calcium phosphate's own weight.

106 . The implant material of claim 94 , wherein the calcium phosphate is capable of absorbing an amount of the solution comprising PDGF that is equal to at least about 300% of the calcium phosphate's own weight.

107 . The implant material of claim 94 , wherein the implant material is resorbable such that at least 80% of the calcium phosphate is resorbed within one year of being implanted.

108 . The implant material of claim 94 , wherein the calcium phosphate is poorly crystalline hydroxyapatite.