IP Library Granted Patent US 10,094,847
Granted Patent B2
US 10,094,847 · App. 15/222,173 · Granted Oct 9, 2018

Automated sample processing instruments, systems, processes, and methods

Inventor: Rolf Silbert (Del Mar, CA)
Assignee: GEN-PROBE INCORPORATED
G01N35/04G01N35/0099G01N35/026G01N35/10G01N35/109G01N2035/0412G01N2035/0491G01N2035/0496
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Quick Facts
Patent No.
US 10,094,847
App. No.
15/222,173
Granted
Oct 9, 2018
Kind
B2
Abstract

An automated instrument for processing a sample includes a first lock configured to move between a locked configuration and an unlocked configuration. The first lock is configured to be engaged with a first movable holding structure in the locked configuration to secure the first holding structure within the automated instrument. The first lock is configured to be disengaged from the first holding structure in the unlocked configuration to allow movement of the first holding structure within the automated instrument. The automated instrument also includes a robotic arm movable within the automated instrument and configured to move the first lock between the locked configuration and the unlocked configuration. The first holding structure is configured to hold a sample processing device and configured to move within the automated instrument when the first lock is in the unlocked configuration. The robotic arm can also be configured to move the sample processing device within the system.

Claims (41)

1. An automated instrument for processing a sample, the instrument comprising:

a movable first rack configured to hold a sample containing receptacle, the first rack defining a first recess;

a movable second rack configured to hold a processing receptacle, the second rack defining a second recess;

a first lock comprising a first locking pin configured to be received in the first recess, the first lock configured to move between a locked configuration and an unlocked configuration, wherein the first lock is configured to be engaged with the first rack in the locked configuration of the first lock to secure the first rack within the automated instrument, and wherein the first lock is disengaged from the first rack in the unlocked configuration of the first lock to allow movement of the first rack within the automated instrument;

a second lock comprising a second locking pin configured to be received in the second recess, the second lock configured to move between a locked configuration and an unlocked configuration, wherein the second lock is configured to be engaged with the second rack in the locked configuration of the second lock to secure the second rack within the automated instrument, and wherein the second lock is configured to be disengaged from the second rack in the unlocked configuration of the second lock to allow movement of the second rack within the automated instrument;

a robotic arm movable within the automated instrument; and

a controller configured to control the robotic arm to:

(i) engage and move the first lock to the locked configuration of the first lock,

(ii) engage and move the first lock to the unlocked configuration of the first lock,

(iii) engage and move the second lock to the locked configuration of the second lock,

(iv) engage and move the second lock to the unlocked configuration of the second lock, and

(v) pick-and-place the sample containing receptacle, the processing receptacle, or both within the automated instrument.

2. The automated instrument of claim 1 , wherein:

the first locking pin has at least one prong configured to be received within the first recess; and

the second locking pin has at least one prong configured to be received within the second recess.

3. The automated instrument of claim 2 , wherein the first recess comprises a through hole.

4. The automated instrument of claim 2 , wherein the first rack comprises a tab extending from a surface of the first rack and defining the first recess.

5. The automated instrument of claim 4 , further comprising:

a first bay configured to movably receive the first rack and having a first panel defining a first opening configured to receive the tab, wherein the first locking pin is movably coupled to the first bay such that the at least one prong of the first locking pin is received within the first recess when the tab is received within the first opening and the first lock is in the locked configuration; and

a second bay configured to movably receive the second rack, wherein the second locking pin is movably coupled to the second bay such that the at least one prong of the second locking pin is received within the second recess when the second lock is in the locked configuration.

6. The automated instrument of claim 2 , wherein the first rack has a tapered surface that defines the first recess.

7. The automated instrument of claim 2 , wherein the second recess is a pocket defined by a surface of the second rack facing the second lock.

8. The automated instrument of claim 7 , wherein the second rack defines a third recess, the third recess being a pocket defined by the surface of the second rack facing the second lock, and wherein the at least one prong of the second locking pin comprises a first prong and a second prong configured to be received within the second recess and the third recess, respectively, when the second lock is in the locked configuration.

9. The automated instrument of claim 1 , wherein the controller is configured to control the robotic arm to pick-and-place the sample containing receptacle within the automated instrument.

10. The automated instrument of claim 1 , wherein the controller is configured to control the robotic arm to pick-and-place the processing receptacle within the automated instrument.

11. The automated instrument of claim 1 , further comprising:

a movable third rack configured to hold a second sample containing receptacle, the third rack defining a third recess;

a third lock comprising a third locking pin configured to be received in the third recess, the third lock configured to move between a locked configuration and an unlocked configuration, wherein the third lock is configured to be engaged with the third rack in the locked configuration of the third lock to secure the third rack within the automated instrument, wherein the third lock is configured to be disengaged from the third rack in the unlocked configuration of the third lock to allow movement of the third rack within the automated instrument, and wherein the controller is configured to control the robotic arm to engage and move the third lock between the locked configuration and the unlocked configuration.

12. The automated instrument of claim 11 , wherein the controller is configured to control the robotic arm to pick-and-place the second sample containing receptacle within the automated instrument.

13. The automated instrument of claim 1 , further comprising:

a movable third rack configured to hold a second processing receptacle, the third rack defining a third recess;

a third lock comprising a third locking pin configured to be received in the third recess, the third lock configured to move between a locked configuration and an unlocked configuration, wherein the third lock is configured to be engaged with the third rack in the locked configuration of the third lock to secure the third rack within the automated instrument, wherein the third lock is configured to be disengaged from the third rack in the unlocked configuration of the third lock to allow movement of the third rack within the automated instrument, and wherein the controller is configured to control the robotic arm to engage and move the third lock between the locked configuration and the unlocked configuration.

14. The automated instrument of claim 13 , wherein the controller is configured to control the robotic arm to pick-and-place the second processing receptacle within the automated instrument.

15. The automated instrument of claim 1 , further comprising:

a movable holding structure configured to hold a sample processing device, the movable holding structure defining a third recess;

a third lock comprising a third locking pin configured to be received in the third recess, the third lock configured to move between a locked configuration and an unlocked configuration, wherein the third lock is configured to be engaged with the holding structure in the locked configuration to secure the holding structure within the automated instrument, wherein the third lock is configured to be disengaged from the holding structure in the unlocked configuration to allow movement of the holding structure within the automated instrument, and wherein the controller is configured to control the robotic arm to engage and move the third lock between the locked configuration and the unlocked configuration.

16. The automated instrument of claim 15 , wherein the holding structure is a drawer.

17. The automated instrument of claim 15 , wherein the sample processing device is a reagent containing receptacle.

18. The automated instrument of claim 15 , wherein the sample processing device is a pipette tip.

19. The automated instrument of claim 17 , wherein the controller is configured to control the robotic arm to pick-and-place the reagent containing receptacle within the automated instrument.

20. The automated instrument of claim 18 , wherein the controller is configured to control the robotic arm to engage and move the pipette tip within the automated instrument.

Assignments (5)
RELEASE OF SECURITY INTEREST RECORDED AT REEL/FRAME 040208/0109 Recorded Apr 23, 2026
From: BANK OF AMERICA, N.A., AS COLLATERAL AGENT
To: HOLOGIC, INC.; GEN-PROBE INCORPORATED
Reel/Frame 075471/0100 →
SECURITY INTEREST Recorded Apr 8, 2026
From: BIOTHERANOSTICS, INC.; GEN-PROBE INCORPORATED; GEN-PROBE PRODESSE, INC.; CYTYC CORPORATION; SUROS SURGICAL SYSTEMS, INC.; GYNESONICS, INC.; BOLDER SURGICAL, LLC; FAXITRON BIOPTICS, LLC; HEALTH BEACONS, INC.; HOLOGIC, INC.
To: ROYAL BANK OF CANADA, AS COLLATERAL AGENT
Reel/Frame 075462/0440 →
SECURITY INTEREST Recorded Oct 14, 2019
From: HOLOGIC, INC.; CYNOSURE, LLC; CYTYC CORPORATION; FAXITRON BIOPTICS, LLC; FOCAL THERAPEUTICS, INC.; GEN-PROBE INCORPORATED
To: BANK OF AMERICA, N.A., AS COLLATERAL AGENT
Reel/Frame 050719/0701 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 14, 2016
From: SILBERT, ROLF
To: GEN-PROBE INCORPORATED
Reel/Frame 040729/0302 →
SECURITY AGREEMENT Recorded Oct 3, 2016
From: HOLOGIC, INC.; GEN-PROBE INCORPORATED
To: BANK OF AMERICA, N.A., AS COLLATERAL AGENT
Reel/Frame 040208/0109 →
Continuity (2)
Provisional Application 62199690 · Jul 31, 2015
Related Publication 20170052205A1 · Feb 23, 2017