IP Library Granted Patent US 10,722,539
Granted Patent B2
US 10,722,539 · App. 15/223,831 · Granted Jul 28, 2020

Cadaveric derived wound treatment and method of use

Inventor: Timothy R. Brahm (Germantown, TN)
Assignee: Brahm Holdings, LLC
A61K35/34A61K9/0014A61K9/0019A61K9/703A61K35/28A61K35/35A61K35/36A61K38/39A61K45/00A61K45/06A61K47/42
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Quick Facts
Patent No.
US 10,722,539
App. No.
15/223,831
Granted
Jul 28, 2020
Kind
B2
Abstract

Wound treatment compositions obtained from cadaveric tissues are provided. Methods of processing such tissues to form wound treatment compositions are provided. Methods of treating a wound are also provided.

Claims (16)

1. A wound treatment composition comprising:

cadaveric muscle particles substantially devoid of lactic acid, alcohol, or acetic acid, the cadaveric muscle particles having a size of from 1 μm to 2 mm; and

a pharmaceutically acceptable liquid comprising lysine,

wherein the wound treatment composition is formulated to be self-shaping,

wherein the wound treatment composition has a viscosity greater than 1 mPas but less than 10 mPas as determined by ASTM D445.

2. The wound treatment composition of claim 1 , wherein the composition is flowable.

3. The wound treatment composition of claim 1 , wherein the composition is formulated as a paste or putty.

4. The wound treatment composition of claim 1 , wherein the wound treatment further comprises cadaveric stem cells, cadaveric cytokines, cadaveric hormones, cadaveric biological response modifiers, cadaveric collagen, cadaveric extracellular matrix, or any combination thereof.

5. The wound treatment of claim 1 , further comprising a collagen source.

6. The wound treatment of claim 5 , wherein the collagen source is a collagen pad.

7. The wound treatment composition of claim 1 , wherein the muscle tissue is voluntary muscle tissue.

8. The wound treatment composition of claim 1 , wherein the wound treatment further comprises one or more germicides, antibiotics, analgesics, local anesthetic agents.

9. The wound treatment composition of claim 1 , wherein the pharmaceutically acceptable liquid further comprises tris(hydroxymethyl)aminomethane).

10. The wound treatment composition of claim 1 , wherein the pharmaceutically acceptable liquid further comprises N-2-hydroxyethylpiperazine-N′-2-ethanesulfonic acid (HEPES).

11. The wound treatment composition of claim 1 , wherein the pharmaceutically acceptable liquid further comprises 3-(N-morpholino) propanesulfonic acid (MOPS).

12. The wound treatment composition of claim 1 , wherein the pharmaceutically acceptable liquid further comprises sodium acetate.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 23, 2017
From: BRAHM, TIMOTHY R.
To: BRAHM HOLDINGS, LLC
Reel/Frame 041047/0141 →
Continuity (2)
Provisional Application 62198711 · Jul 30, 2015
Related Publication 20170027992A1 · Feb 2, 2017