INFLATION MEDIA FOR IMPLANTS
An inflatable implant is disclosed. The inflatable implant comprises at least one inflation channel for forming an inflatable structure of the inflatable implant; and an inflation media disposed within the at least one inflation channel, wherein the inflation media comprises a mixture of an epoxy resin and a hardener, the mixture is configured to gel at about 37° C. in less than about 2.5 hours after mixing to form a gelled mixture.
1 . A inflatable implant comprising
at least one inflation channel for forming an inflatable structure of the inflatable implant; and
an inflation media disposed within the at least one inflation channel, wherein the inflation media comprises a mixture of an epoxy resin and a hardener, the mixture is configured to have an average viscosity of less than about 100 cps at about 37° C. over the first 10 minutes after mixing, and gel at about 37° C. in less than about 2.5 hours after mixing to form a gelled mixture.
2 . The inflatable implant of claim 1 , wherein the gelled mixture has a tensile strength of greater than about 20 MPa when fully hydrated.
3 . The inflatable implant of claim 1 , wherein the mixture reaches at least about 70% cure in less than 20 hours.
4 . The inflatable implant of claim 1 , wherein the mixture exhibits less than about 10% creep when it is substantially completely cured.
5 . The inflatable implant of claim 1 , wherein the mixture has a fatigue life longer than about 600 million cycles when loaded at 1.5 MPa.
6 . The inflatable implant of claim 1 , wherein the surface of the inflatable implant is maintained at a temperature below 42° C.
7 . The inflatable implant of claim 1 , wherein
the epoxy resin comprising a first compound having at least one N,N-bis(oxiran-2-ylmethyl)aniline segment and a second compound having at least two oxirane groups on a backbone of no more than five carbons; and
the hardener comprising at least one cycloaliphatic amine.
8 . (canceled)
9 . (canceled)
10 . (canceled)
11 . (canceled)
12 . (canceled)
13 . (canceled)
14 . (canceled)
15 . (canceled)
16 . (canceled)
17 . (canceled)
18 . (canceled)
19 . (canceled)
20 . (canceled)
21 . (canceled)
22 . (canceled)
23 . (canceled)
24 . A prosthetic valve implant delivery system comprising:
a deployment catheter comprising an inflation tube and a prosthetic valve comprising an inflatable structure in communication with the inflation tube; and
an inflation media of any one of claim 1 for inflating the inflatable structure through the inflation tube.
25 . The prosthetic valve implant delivery system of claim 24 , wherein the deployment catheter has an inner diameter of 18 French.
26 . A method of implanting a prosthetic valve within the heart, the method comprising:
translumenally advancing a prosthetic valve comprising an inflatable structure to a position proximate a native valve of the heart;
mixing the epoxy resin and the hardener in the inflation media of any one of claim 1 to form an epoxy mixture; and
inflating the inflatable structure with the epoxy mixture.
27 . The method of claim 26 , wherein the epoxy mixture is formed ex-vivo and delivered to the inflatable structure.
28 . The method of claim 26 , wherein the epoxy mixture has an initial viscosity of less than about 50 cps after mixing, and is soluble in an aqueous environment.
29 . The method of claim 26 , wherein the epoxy mixture has a tensile strength of greater than about 40 MPa after becoming fully hydrated.
30 . The method of claim 26 , wherein the epoxy mixture cures to a semi-solid gel in less than about 4 hours at about 37° C.
31 . A method of treating a patient, comprising:
advancing a deployment catheter to a position proximate a native valve of the heart, the deployment catheter comprising an inflation tube and a prosthetic valve comprising an inflatable structure in communication with the inflation tube;
deploying the prosthetic valve at the cardiovascular site;
inflating the inflatable structure with an epoxy mixture comprising the inflation media of any one of claim 1 through the inflation tube; and
detaching the deployment catheter from the prosthetic valve and removing the deployment catheter from the patient.