Methods and devices to curb appetite and/or to reduce food intake
The present invention relates to devices and methods of operating the devices that contribute to curbing appetite and/or reducing food intake. In some embodiments, the methods and devices of the present invention include as intestinal/duodenal insert comprising an elongated member with at least one flow reduction element that can cause the stimulation of one or more biological signals of satiety. Some embodiments of the inserted device are anchored at the duodenal site by an anchoring member residing in the stomach, other embodiments of the device are stabilized at a targeted site by appropriate dimensions of length as well as one or more angled portions of the device that correspond to angled portions of the targeted site in the dodenum. Embodiments of the device exert effects by virtue of physical presence, as well as by more active forms of intervention, including release of bioactive materials and electrical stimulation of neurons.
1. A gastrointestinal insert, comprising:
an elongated member configured to be placed in a patient's duodenum, wherein the elongated member has a proximal end, a distal end, and a longitudinal axis extending from the proximal end to the distal end;
a plurality of porous flow reduction elements comprising mesh baskets along the elongated member, the mesh baskets comprising a shape-memory material and expandable from a stowed configuration to a deployed substantially spherical configuration; and
an anchor connected to the proximal end of the elongated member, wherein the anchor is configured to be placed in a stomach to anchor the mesh baskets in the duodenum.
2. The gastrointestinal insert of claim 1 , wherein the mesh baskets in the substantially spherical configuration define an enclosed space.
3. The gastrointestinal insert of claim 1 , wherein the longitudinal axis is curved into a curved shape that mimics a portion of a small intestine.
4. The gastrointestinal insert of claim 3 , wherein the elongated member is configured to bend and return to the curved shape after insertion into the duodenum.
5. The gastrointestinal insert of claim 1 , wherein the mesh baskets in the deployed substantially spherical configuration are configured to reduce the flow rate of chyme in a patient's small intestine.
6. The gastrointestinal intestinal insert of claim 1 , wherein the mesh baskets in the deployed substantially spherical configuration encircle the elongated member.
7. The gastrointestinal insert of claim 1 , wherein the elongated member is solid.
8. The gastrointestinal insert of claim 1 , wherein the mesh baskets are contiguous with the elongated member.
9. The gastrointestinal insert of claim 1 , wherein the mesh baskets in the deployed substantially spherical configuration are concentrically arranged about the elongated member.
10. The gastrointestinal insert of claim 1 , wherein the shape memory material is a polymer.
11. The gastrointestinal insert of claim 1 , wherein the shape memory material is a metal alloy.
12. The gastrointestinal insert of claim 1 , wherein the insert is configured to generate a hormonal signal of satiety when the mesh baskets are in the duodenum.
13. The gastrointestinal insert of claim 1 , wherein the anchor is configured to restrict distal migration of the elongated member.
14. The gastrointestinal insert of claim 1 , wherein the elongated member comprises a shape memory material.