CELLULAR CONTROL AND TISSUE REGENERATION SYSTEMS AND METHODS
A system for in-vivo and ex-vivo tissue regeneration and cellular control, manipulation and management includes a source of cell manipulating factors, which are administered to a therapy zone via active pressure-differential components including a pump and a controller, or pulse-waves generated passively. A plate comprising tissue or an inert, bio-compatible material is provided in the therapy zone in proximity to a fluid flow manifold and tissue scaffolding. An embodiment of a medical cellular factor control system and method includes an implanted bio-reactor and a force transducer configured for supplying one or more cell-manipulating factors to a therapy zone surrounding the bio-reactor. Optionally, a concave-curved, internal reflector can be implanted in proximity to the bio-reactor, the internal reflector being configured for amplifying pressure waves in the therapy zone.
1 . A medical cellular factor control system for a tissue therapy zone, which system comprises:
a source of a cell-manipulating factor;
a factor placement device connected to said factor source and configured for placing said factor in tissue in said therapy zone, said factor placement device including a force transducer configured for applying a force in said therapy zone;
a non-dermal derived tissue scaffolding configured for implantation within in-vivo tissue in said therapy zone; and
wherein said tissue scaffolding is configured for enhancing cellular-level reactions within said therapy zone.
2 . The medical cellular factor control system according to claim 1 , which includes:
said force transducer including a differential fluid pressure device configured for providing pressure impulses within said therapy zone for factor placement and cellular manipulation.
3 . The medical cellular factor control system according claim 2 , which includes:
an ex vivo fluid pressure control device; and
said fluid pressure control device configured for pulsing fluid pressure in vivo.
4 . The medical cellular factor control system according to claim 3 , which includes:
said fluid pressure control device including an external pump; and
a fluid conduit configured for ex vivo connection to said pump and in vivo connection to said non-dermal derived tissue scaffolding and communicating fluid between said pump and said scaffolding.
5 . The medical cellular factor control system according to claim 1 , wherein said factor is chosen from among the group comprising: physical contact, fluidic contact, fluid pressure gradient, pressure wave, osmolar, osmotic, oncotic, mechano/transductive, electromagnetic force (EMF), pharmacological, chemical, antimicrobial, fluidic, bioengineered cells for seeding, thermal, acoustic, and ultrasound.
6 . The medical cellular factor control system according to claim 2 , wherein said force transducer includes a pressure differential manifold configured for placement in vivo in said therapy zone.
7 . The medical cellular factor control system according to claim 2 , which includes:
said impulses comprising systolic/diastolic in vivo blood pressure differentials; and
said force transducer configured for stimulating cellular activity in said therapy zone with in vivo blood pressure pulsations.
8 . The medical cellular factor control system according to claim 1 wherein:
said scaffolding structure includes a cell growth promoter chosen from among the group consisting of: cells for cell seeding, biomaterials for tissue engineering, pharmacological drugs, vitamins, and nutrients;
said scaffolding structure is biodegradable or biocompatible; and
said structure is configured for remote implantation.
9 . The medical cellular factor control system according to claim 1 , wherein said force transducer includes a concave-curved internal reflector configured for placement in said therapy zone and amplifying pressure waves therein.
10 . A medical cellular factor control system for a tissue therapy zone, which system comprises:
a source of a cell-manipulating factor;
a factor placement device connected to said factor source and configured for placing said factor in tissue in said therapy zone;
a force transducer configured for placement in said tissue and applying said factor to said tissue in said therapy zone;
a programmable controller connected to and controlling said factor placement device and said force transducer;
a non-dermal derived tissue scaffolding configured for implantation within in-vivo tissue in said therapy zone; and
wherein said tissue scaffolding is configured for enhancing cellular-level reactions within said therapy zone.
11 . The medical cellular factor control system according to claim 10 , which includes:
a sensor connected to said therapy zone and said controller;
wherein said sensor is configured for providing an input signal to said controller corresponding to an in vivo condition.
12 . The medical cellular factor control system according to claim 11 wherein said in vivo condition detected by said sensor is chosen from among the group comprising: microbial activity; therapy zone healing status; blood pressure; pharmacological presence; lymphatic fluid presence; temperature; infection; antibiotic levels; and protein levels.
13 . The medical cellular factor control system according to claim 10 , which includes a cell manipulating factor chosen from the group comprising: physical contact, fluidic contact, fluid pressure gradient, pressure wave, osmolar, osmotic, oncotic, mechano/transductive, electromagnetic force (EMF), pharmacological, chemical, antimicrobial, fluidic, bioengineered cells for seeding, thermal, acoustic, and ultrasound.