Topical compositions
The present invention relates generally to methods and compositions useful for a topical composition comprising encapsulated resveratrol, oligopeptide-1, niacinamide, Opuntia ficus - indica extract, Prunus mume extract, algae extract, malachite extract, adenosine, and/or Opuntia tuna fruit extract.
1. A method of reducing oxidative damage of skin comprising applying to oxidant damaged skin a topical composition comprising encapsulated resveratrol, oligopeptide-1, niacinamide, and Prunus mume leaf aqueous extract, and optionally one or more of Opuntia tuna fruit extract, malachite extract, adenosine, algae extract, or Opuntia ficus - indica fruit extract, wherein the combination of encapsulated resveratrol, oligopeptide-1, and niacinamide reduces oxidative damage in the skin, and wherein the oligopeptide-1 comprises the sequence of caprooyl-Gly-His-Lys-Lys.
2. The method of claim 1 , wherein further the oligopeptide-1 inhibits tyrosinase, increases production of elastin, stimulates collagen production and/or secretion, and/or inhibits TNF-α; niacinamide inhibits melanogenesis and Prunus mume leaf aqueous extract stimulates collagen production and/or secretion, increases laminin production, and/or increases antioxidant capacity of the composition; and optionally Opuntia tuna fruit extract inhibits COX-1, inhibits COX-2, inhibits lipoxygenase, and/or inhibits TNF-α; malachite extract inhibits MMP1, inhibits COX-1, inhibits COX-2, inhibits lipoxygenase, and/or increases antioxidant capacity of the composition; algae extract increases skin barrier integrity; and/or Opuntia ficus - indica fruit extract inhibits COX-1, inhibits COX-2, inhibits lipoxygenase, and/or inhibits TNF-α.
3. The method of claim 1 , wherein the topical composition comprises:
0.00001 to 0.1% by weight of encapsulated resveratrol, 0.0000001 to 0.01% by weight of oligopeptide-1, 0.001 to 3% by weight of niacinamide, and 0.01 to 3% by weight of Prunus mume leaf aqueous extract: and
optionally one or more of 0.00001 to 0.01% by weight of Opuntia tuna fruit extract, 0.00001 to 0.1% by weight of malachite extract, 0.001 to 1% by weight of adenosine, 0.001 to 1% by weight of algae extract, or 0.001 to 3% by weight of Opuntia ficus - indica fruit extract.
4. The method of claim 1 , wherein the topical composition is applied to the skin daily.
5. The method of claim 2 , wherein:
the oligopeptide-1 inhibits tyrosinase, increases production of elastin, stimulates collagen production and/or secretion, and/or inhibits TNF-α; niacinamide inhibits melanogenesis; and Prunus mume leaf extract stimulates collagen production and/or secretion, increases laminin production, and/or increases antioxidant capacity of the composition, and
optionally wherein Opuntia tuna fruit extract inhibits COX-1, inhibits COX-2, inhibits lipoxygenase, and/or inhibits TNF-α; malachite extract inhibits MIMP1, inhibits COX-1, inhibits COX-2, inhibits lipoxygenase, and/or increases antioxidant capacity of the composition; algae extract increases skin barrier integrity; and/or Opuntia ficus - indica fruit extract inhibits COX-1, inhibits COX-2, inhibits lipoxygenase, and/or inhibits TNF-α.
6. The method of claim 2 , wherein:
the oligopeptide-1 inhibits tyrosinase, increases production of elastin, stimulates collagen production and/or secretion, and inhibits TNF-α; niacinamide inhibits melanogenesis; and Prunus mume leaf extract stimulates collagen production and/or secretion, increases laminin production, and increases antioxidant capacity of the composition; and
optionally wherein Opuntia tuna fruit extract inhibits COX-1, inhibits COX-2, inhibits lipoxygenase, and inhibits TNF-α; malachite extract inhibits MIMP1, inhibits COX-1, inhibits COX-2, inhibits lipoxygenase, and increases antioxidant capacity of the composition; algae extract increases skin barrier integrity; and/or Opuntia ficus - indica fruit extract inhibits COX-1, inhibits COX-2, inhibits lipoxygenase, and inhibits TNF-α.
7. The method of claim 2 , wherein the topical composition further comprises water, hydroxyacetophenone, and tocopheryl acetate.
8. The method of claim 7 , wherein the topical composition comprises:
0.00001 to 0.1% by weight of encapsulated resveratrol, 0.0000001 to 0.01% by weight of oligopeptide-1, 0.001 to 3% by weight of niacinamide, 0.01 to 3% by weight of Prunus mume leaf aqueous extract, 25 to 98% by weight of water, 0.01 to 3% by weight of hydroxyacetophenone, and 0.001 to 1% by weight of tocopheryl acetate,
and optionally one or more of 0.00001 to 0.01% by weight of Opuntia tuna fruit extract, 0.00001 to 0.1% by weight of malachite extract, 0.001 to 1% by weight of adenosine, 0.001 to 1% by weight of algae extract, or 0.001 to 3% by weight of Opuntia ficus - indica fruit extract.
9. The method of claim 2 , wherein the topical composition further comprises isohexadecane, dimethicone, aluminum starch octenyl succinate, and caprylic/capric triglyceride.
10. The method of claim 9 , wherein the topical composition comprises:
0.00001 to 0.1% by weight of encapsulated resveratrol, 0.0000001 to 0.01% by weight of oligopeptide-1, 0.001 to 3% by weight of niacinamide, 0.01 to 3% by weight of Prunus mume leaf aqueous extract, 0.01 to 15% by weight of isohexadecane, 0.01 to 10% by weight of dimethicone, 1 to 10% by weight of aluminum starch octenyl succinate, and 0.01 to 3% by weight of caprylic/capric triglyceride,
and optionally one or more of 0.00001 to 0.01% by weight of Opuntia tuna fruit extract, 0.00001 to 0.1% by weight of malachite extract, 0.001 to 1% by weight of adenosine, 0.001 to 1% by weight of algae extract, or 0.001 to 3% by weight of Opuntia ficus - indica fruit extract.