IP Library Granted Patent US 10,349,901
Granted Patent B2
US 10,349,901 · App. 15/234,953 · Granted Jul 16, 2019

Shock probability determination system and method

Inventors: Markus J. Osypka (La Jolla, CA); Clemens Feige (Berlin, DE); Marcel D. Gestewitz (Berlin, DE); Florin-Viorel Petrov (Berlin, DE); Yasser A. Nassef (Dubai, AE)
Assignee: OSYPKA MEDICAL GMBH
A61B5/7278A61B5/01A61B5/029A61B5/02028A61B5/02055A61B5/0295A61B5/02108A61B5/0816A61B5/7225A61B5/7264A61B5/7275G06F19/3418G16H50/20G16H50/30A61B5/021A61B5/02007A61B5/743
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Quick Facts
Patent No.
US 10,349,901
App. No.
15/234,953
Filed
Aug 11, 2016
Granted
Jul 16, 2019
Kind
B2
Art Unit
3791
USPC
600/483
Abstract

A shock probability determination system and method provides an output of probabilities for different types of shock based on input of selected patient demographic parameters and current clinical parameter values as well as normal ranges for each clinical parameter based on patient demographic data. The probability of different types of shock is determined based on comparison of current clinical parameter values of selected patient hemodynamic parameters to a normal range for each hemodynamic parameter. In one aspect, probabilities of cardiogenic shock, hypovolemic shock, septic shock, and anaphylactic shock are determined. In another aspect, a fluid status indicator is determined based on real-time probability of hypovolemic shock.

Claims (37)

1. A computer implemented method of determining shock probabilities for a plurality of shock types, wherein one or more computing devices comprising data storage and a hardware processor are programmed to perform steps comprising, during treatment of a patient by a healthcare provider:

receiving or retrieving demographic data of the patient undergoing treatment;

receiving input of a plurality of currently measured values of selected variable clinical parameters of the patient, comprising at least hemodynamic parameters, from a hemodynamic monitor connected to the patient;

comparing each clinical parameter value to a normal range for that parameter based on input or stored patient demographic data;

determining probabilities of two or more shock types comprising at least cardiogenic shock and hypovolemic shock using some or all of the clinical parameter values relative to the normal range for the respective parameter values, wherein selected groups of clinical parameters are assigned to the respective shock types for determining the shock probability;

displaying a shock probability for each shock type on an output display unit;

determining a patient's fluid status indicator FluidDx=1−P HYPO , where P HYPO is the hypovolemic shock probability; and

displaying the fluid status indicator on the output display device and periodically updating the fluid status indicator during the treatment of the patient, so as to alert the healthcare provider to supply fluid to the patient or treat a condition of high blood volume based on a level of the fluid status indicator.

2. A system for determining probabilities of a plurality of different shock types based on patient clinical parameters, the system comprising:

a non-transitory computer readable medium configured to store executable programmed modules;

a processor communicatively coupled with the non-transitory computer readable medium and configured to execute programmed modules stored therein;

an output display unit; and

one or more programmed modules stored in the non-transitory computer readable medium and configured to be executed by the processor, the one or more programmed modules configured to, during treatment of a patient by a healthcare provider:

receive or retrieve demographic data of the patient undergoing treatment;

receive input of a plurality of currently measured values of selected clinical parameters of the patient, comprising at least hemodynamic parameters, from a hemodynamic monitor connected to the patient;

assign selected groups of clinical parameters to respective different shock types;

compare each currently measured clinical parameter value to a normal range for that parameter based on determined or stored patient demographic data;

determine probabilities of the respective different shock types based on the comparison of each current clinical parameter value in the respective group to the normal range for the respective clinical parameter; and

display a shock probability for each shock type on an output display unit,

wherein the one or more programmed modules are further configured to determine a generic shock probability M (generic shock condition “improbable”) using at least two selected clinical parameters indicative of any type of shock condition being present, and to compute a restricted probability of at least some shock types based on the determined generic shock probability if M(generic shock condition “improbable”) is greater than zero according to the following:

P *(shock type)= P (shock type)*(1− M (generic shock condition,‘improbable’)),

where P*(shock type)=restricted shock probability due to a generic shock condition ‘improbable’, and P(shock type)=unrestricted probability of the respective shock type prior to generic shock restriction,

where one of the shock types is hypovolemic shock, and

wherein the one or more programmed modules are further configured to determine a patient's fluid status indicator FluidDx=1−P HYPO , where P HYPO is the unrestricted hypovolemic shock probability, display the fluid status indicator on the output display device, and periodically update the fluid status indicator during treatment of the patient, so as to alert the healthcare provider to supply fluid to the patient or treat a condition of high blood volume based on a level of the fluid status indicator.

3. The system of claim 2 , wherein the one or more programmed modules are further configured to determine updated shock probabilities and an updated fluid status indicator at periodic intervals based on changes in the input clinical parameter values over time, and to display updated shock probabilities and fluid status indicators on the output display device in the form of one or more of numeric values, a bar chart and a trend graph illustrating variation in the probability of each shock type and the fluid status indicator over time.

4. A system for monitoring a patient's fluid status indicator for fluid management, the system comprising:

a non-transitory computer readable medium configured to store executable programmed modules;

a processor communicatively coupled with the non-transitory computer readable medium and configured to execute programmed modules stored therein;

an output display unit; and

one or more programmed modules stored in the non-transitory computer readable medium and configured to be executed by the processor, the one or more programmed modules configured to, during treatment of a patient by a healthcare provider:

receive demographic data or retrieve stored demographic data of a patient undergoing treatment;

receive input of a plurality of currently measured values of selected variable clinical parameters of the patient, comprising at least hemodynamic parameters, from a hemodynamic monitor connected to the patient, the clinical parameters being selected for determining a current probability of hypovolemic P(shock hypovolemic );

compare each received clinical parameter value to a normal range for that parameter based on input or stored patient demographic data;

determine the probability of hypovolemic shock based on the comparison of each received clinical parameter value with the normal range for the respective clinical parameter;

determine a fluid status indicator FluidDx indicative of blood volume from the following relationship: FluidDx=1−P(shock hypovolemic ); and

display the fluid status indicator on the output display unit and periodically update the fluid status indicator during the treatment of the patient, so as to alert the healthcare provider to supply fluid to the patient or treat a condition of high blood volume based on a level of the fluid status indicator.

5. The system of claim 4 , wherein the programmed modules are further configured to monitor the selected clinical parameter values, to determine updated probabilities of hypovolemic shock and updated fluid status indicators on an ongoing basis based on current clinical parameter values, and to display updated fluid status parameters on the output display unit, wherein the output display comprises one or more of a numeric display, a bar chart, and a trend graph illustrating variation in the fluid status parameter over time.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 11, 2016
From: OSYPKA, MARKUS J.; FEIGE, CLEMENS; GESTEWITZ, MARCEL D.; PETROV, FLORIN-VIOREL; NASSEF, YASSER A.
To: OSYPKA MEDICAL GMBH
Reel/Frame 039412/0248 →
Continuity (2)
Provisional Application 62207599 · Aug 20, 2015
Related Publication 20170053077A1 · Feb 23, 2017
Cited By (4)
US 12,226,733 US 12,347,555 US 12,427,474 US 12,594,524