LPA RECEPTOR MODULATORS FOR BROWN FAT DIFFERENTIATION
Described herein is a method of increasing brown fat differentiation or increasing energy expenditure in a subject in need thereof, the method comprising administering to the subject an LPA receptor modulator, or a pharmaceutically acceptable salt, solvate, polymorph, prodrug, metabolite, deuteride, N-oxide, stereoisomer, or isomer thereof.
1 . A method of increasing brown fat differentiation in a subject in need thereof, the method comprising administering to the subject an LPA receptor modulator, or a pharmaceutically acceptable salt, solvate, polymorph, prodrug, metabolite, deuteride, N-oxide, stereoisomer, or isomer thereof.
2 . The method of claim 1 , wherein the LPA receptor modulator has the structure:
3 . The method of claim 1 , wherein the LPA receptor modulator has the structure:
4 . The method of claim 1 , wherein the LPA receptor modulator has the structure:
5 . The method of claim 1 , wherein the LPA receptor modulator has the structure:
6 . The method of claim 1 , wherein the LPA receptor modulator promotes or increases weight loss in the subject.
7 . The method of claim 1 , wherein the LPA receptor modulator promotes or increases insulin sensitization.
8 . The method of claim 1 , wherein the LPA receptor modulator is minimally systemically absorbed.
9 . The method of claim 1 , wherein the LPA receptor modulator is an LPA receptor antagonist.
10 . A method for increasing energy expenditure in a subject in need thereof, the method comprising administering to the subject an LPA receptor modulator, or a pharmaceutically acceptable salt, solvate, polymorph, prodrug, metabolite, deuteride, N-oxide, stereoisomer, or isomer thereof, to activate differentiation of the white adipose tissue into brown fat cells in the subject, wherein the differentiated brown fat cells promote energy expenditure thereby increasing energy expenditure in the mammal.
11 . The method of claim 10 , wherein the LPA receptor modulator has the structure:
12 . The method of claim 1 , wherein the LPA receptor modulator has the structure:
13 . The method of claim 10 , wherein the LPA receptor modulator has the structure:
14 . The method of claim 10 , wherein the LPA receptor modulator has the structure:
15 . The method of claim 10 , wherein the LPA receptor modulator promotes or increases weight loss in the subject.
16 . The method of claim 10 , wherein the LPA receptor modulator promotes or increases insulin sensitization.
17 . The method of claim 10 , wherein the LPA receptor modulator is minimally systemically absorbed.
18 . The method of claim 10 , wherein the LPA receptor modulator is an LPA receptor antagonist.