EPINEPHRINE-BASED OPHTHALMIC COMPOSITIONS FOR INTRAOCULAR ADMINISTRATION AND METHODS FOR FABRICATING THEREOF
Pharmaceutical compositions for intraocular injection are described, the compositions comprise therapeutically effective quantity of lyophilized preservative-free and sulfite-free epinephrine or adrenaline and a metal chelator. Methods for fabricating the compositions and using them for intraocular injections are also described.
1 - 28 . (canceled)
29 . A kit, comprising a bicameral container comprising a first section and a second section separated by a partition, wherein the first section is filled with a quantity of a lyophilized composition and the second section is filled with a quantity of sterilized water, wherein the lyophilized composition comprises
(a) one or more of epinephrine, phenylephrine, EPI-Shugarcaine and tropicamide;
(b) at least one metal chelator;
(c) optionally, at least one anesthetic; and
(d) optionally, at least one non-steroid anti-inflammatory drug.
30 . The kit of claim 29 , wherein epinephrine is in the form of epinephrine hydrochlo-ride.
31 . The kit of claim 29 , wherein the metal chelator is selected from the group consisting of ethylenediaminetetraacetic acid and pharmaceutically acceptable salts thereof.
32 . The kit of claim 31 , wherein the pharmaceutically acceptable salt of ethylenediaminetetraacetic acid is disodium edetate.
33 . The kit of claim 31 , further comprising an additive selected from the group consisting of acetylcysteine, glutathione, ascorbic acid, vitamin E and a balanced salts solution.
34 . The kit of claim 29 , wherein the anesthetic is selected from the group consisting of lidocaine, proparacaine, procaine, tetracaine and combinations thereof.
35 . The kit of claim 29 , wherein the non-steroid anti-inflammatory drug is selected from the group consisting of ketorolac, ketoprofen, flurbiprofen, bromfenac, diclofenac and combinations thereof.
36 . The kit of claim 29 , further optionally comprising a sulfite or preservative.
37 . The kit of claim 36 , wherein the sulfite or preservative is present at a concentration less than about 1 μM.
38 . The kit of claim 29 , wherein the anesthetic is selected from the group consisting of lidocaine, proparacaine, procaine, tetracaine and combinations thereof.
39 . The kit of claim 30 , wherein the non-steroid anti-inflammatory drug is selected from the group consisting of ketorolac, ketoprofen, flurbiprofen, bromfenac, diclofenac and combinations thereof.
40 . A kit, comprising a bicameral container comprising a first section and a second section separated by a partition, wherein the first section is filled with a quantity of a lyophilized composition and the second section is filled with a carrier, wherein the lyophilized composition comprises one or more of epinephrine, phenylephrine, EPI-Shugarcaine and tropicamide.
41 . The kit of claim 40 , wherein the lyophilized composition further comprises
(a) at least one metal chelator;
(b) optionally, at least one anesthetic; and
(c) optionally, at least one non-steroid anti-inflammatory drug.
42 . The kit of claim 41 , wherein epinephrine is in the form of epinephrine hydrochloride.
43 . The kit of claim 41 , wherein the metal chelator is selected from the group consisting of ethylenediaminetetraacetic acid and pharmaceutically acceptable salts thereof.
44 . The kit of claim 41 , further comprising an additive selected from the group consisting of acetylcysteine, glutathione, ascorbic acid, vitamin E and a balanced salts solution.
45 . The kit of claim 41 , wherein the anesthetic is selected from the group consisting of lidocaine, proparacaine, procaine, tetracaine and combinations thereof.
46 . The kit of claim 41 , wherein the non-steroid anti-inflammatory drug is selected from the group consisting of ketorolac, ketoprofen, flurbiprofen, bromfenac, diclofenac and combinations thereof.
47 . The kit of claim 41 , further optionally comprising a sulfite or preservative.
48 . The kit of claim 43 , wherein the anesthetic is selected from the group consisting of lidocaine, proparacaine, procaine, tetracaine and combinations thereof.
49 . The kit of claim 43 , wherein the non-steroid anti-inflammatory drug is selected from the group consisting of ketorolac, ketoprofen, flurbiprofen, bromfenac, diclofenac and combinations thereof.