Granted Patent
B2
US 10,011,612 · App. 15/247,399 · Granted Jul 3, 2018
Aryl, heteroaryl, and heterocyclic compounds for treatment of medical disorders
Inventors:
Jason Allan Wiles (Madison, CT); Avinash S. Phadke (Branford, CT); Milind Deshpande (Madison, CT); Atul Agarwal (Hamden, CT); Dawei Chen (Guilford, CT); Venkat Rao Gadhachanda (Hamden, CT); Akihiro Hashimoto (Branford, CT); Godwin Pais (Hamden, CT); Qiuping Wang (Bethany, CT); Xiangzhu Wang (Branford, CT)
Assignee:
Achillion Pharmaceuticals, Inc.
C07D513/04C07D401/14C07D403/14C07D405/14C07D409/14C07D413/14C07D417/14C07D471/04C07D487/04C07D493/04C07D495/04
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Abstract
Compounds, methods of use, and processes for making inhibitors of complement Factor D comprising Formula I, or a pharmaceutically acceptable salt or composition thereof wherein R 12 or R 13 on the A group is an aryl, heteroaryl or heterocycle (R 32 ) are provided. The inhibitors of Factor D described herein reduce the excessive activation of complement.
Claims (5)
1. A compound of structure:
or a pharmaceutically acceptable salt thereof.
2. A pharmaceutical composition comprising a compound of structure:
or a pharmaceutically acceptable salt thereof; in a pharmaceutically acceptable carrier.
3. A compound of structure:
Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded May 6, 2020
From: WILES, JASON ALLAN; PHADKE, AVINASH S.; DESHPANDE, MILIND; AGARWAL, ATUL; CHEN, DAWEI; GADHACHANDA, VENKAT RAO; HASHIMOTO, AKIHIRO; PAIS, GODWIN; WANG, QIUPING; WANG, XIANGZHU
To: ACHILLION PHARMACEUTICALS, INC.
Reel/Frame 052589/0894 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Aug 29, 2016
From: DESHPANDE, MILIND; PHADKE, AVINASH; WILES, JASON ALLAN; PAIS, GODWIN; HASHIMOTO, AKIHIRO; GADHACHANDA, VENKAT RAO; WANG, QIUPING; CHEN, DAWEI; WANG, XIANGZHU; AGARWAL, ATUL
To: ACHILLION PHARMACEUTICALS, INC.
Reel/Frame 039569/0236 →
Continuity (2)
Provisional Application
62209972
· Aug 26, 2015
Cited By (4)