Biological Buffers with Wide Buffering Ranges
Amines and amine derivatives that improve the buffering range, and/or reduce the chelation and other negative interactions of the buffer and the system to be buffered. The reaction of amines or polyamines with various molecules to form polyamines with differing pKa's will extend the buffering range, derivatives that result in polyamines that have the same pKa yields a greater buffering capacity. Derivatives that result in zwitterionic buffers improve yield by allowing a greater range of stability.
1 . The biological buffer of the following structure:
Where, A, D, are independently chosen from —H, —CH3, —CH2CH3, —CH2CH2CH3, —CH2OH, —CH2O(CH2CH2CH2N) n H where n and m are integers greater than zero.
2 . The biological buffer of claim 1 wherein A is —H and D is —CH3.
3 . The biological buffer of claim 1 wherein A is —H and D is —CH2CH3.
4 . The biological buffer of claim 1 wherein A is —H and D is —CH2CH2CH3.
5 . The biological buffer of claim 1 wherein A is —H and D is —CH2OH.
6 . The biological buffer of claim 1 wherein A is —H and D is —CH3.
7 . The biological buffer of claim 1 wherein A is —CH3 and D is —CH2CH3.
8 . The biological buffer of claim 1 wherein A is —CH3 and D is —CH2CH2CH3.
9 . The biological buffer of claim 1 wherein A is —CH3 and D is —CH2OH.
10 . The biological buffer of claim 1 wherein A is —CH2CH3 and D is —CH2CH2CH3.11.
11 . The biological buffer of claim 1 wherein A is —CH2CH3 and D is —CH2OH.
12 . The biological buffer of claim 1 wherein A is —CH2CH2CH3 and D is —CH2OH
13 . The biological buffer of the following structure:
Where A is chosen from —CH2COOH, —CH2CH2COOH, —CH2CH(CH3)COOH, —CH2CH2SO3H.
14 . The surfactant of the following structure:
Where R is alkyl, saturated or unsaturated, cyclic or acyclic, branched or linear from 2-22 carbons; A, D are independently chosen from —H, —CH3, —CH2CH3, —CH2CH2CH3, —CH2OH.
15 . The surfactant of claim 14 wherein A is —H and D is —CH3.
16 . The surfactant of claim 14 wherein A is —CH3 and D is chosen from —CH3, —CH2CH3, —CH2CH2CH3, —CH2OH.
17 . The surfactant of claim 14 wherein A is —CH3 and D is chosen from —CH2CH2CH3, —CH2OH.
18 . The surfactant of claim 14 wherein A is —CH3 and D is —CH2OH.