Self-assembled nano-structure particle and method for preparing
Novel, nano-structured particles are formed by introducing a selected solid of interest into a structured fluid matrix formed by a dispersion of a small molecule host vessel components, such as a native or modified polysaccharide, cavitand, simple sugar, simple polyol or other similarly structured molecule known to be useful as a host vessel, in an acidic medium or other solvent, whereby the particle size of the introduced solid is reduced and or limited in the structured fluid matrix, by incorporation into or attachment to, the host vessel. The simple, one-step mixing process results in stabilized colloidal dispersions of the nanoparticles useful in a wide variety of applications.
1. A non-mechanical method for reducing the particle size of a solid mineral compound to nanoparticle dimensions, comprising the steps of:
a) adding the solid mineral compound as a guest particle, with agitation, to a high viscosity structured fluid matrix of host vessel molecules dispersed in an acid medium, to form a reaction mixture,
wherein the acid medium comprises polyphosphoric (superphosphoric (105%))
acid and wherein the host vessel molecules comprise β-cyclodextrin;
b) stirring the reaction mixture at an elevated temperature ranging from about 40° C. to about 100° C. for a period of time to allow for particle size reduction and annealing of the solid chemical compound guest particles as they become physically trapped within or attached to the host vessel molecules to form a nanoparticle-based clathrate;
c) quenching the mixture; and
d) separating unreacted host vessel molecules from the mixture to obtain a colloidal dispersion of nanoparticle-based clathrates comprising the solid chemical compound within or attached to the host vessel molecules of the structured fluid matrix,
wherein the particle size of the solid mineral compound is not mechanically reduced prior to adding to the structured fluid matrix, and
wherein distribution of particle sizes achieved for the solid mineral compound are all less than about 600 nanometers.
2. A nanoparticle-based clathrate made by the method of claim 1 .
3. The process method of claim 1 , wherein the mixture is quenched by water.
4. The method of claim 1 further comprising the step of:
adding concentrated sulfuric acid to the reaction mixture after the particle size reduction and annealing step, followed by heating the reaction mixture for an additional period of time prior to quenching.
5. The method of claim 1 , wherein the average particle size of the solid mineral compound achieved is less than about 200 nanometers.
6. A dispersion of the nanoparticle-based clathrates formed by the method of claim 1 .
7. The method of claim 3 , wherein a stabilization compound consisting of glyoxylic acid is added to water for the quenching step.