NASAL DELIVERY
A nasal delivery device for and a method of delivering a substance to a nasal cavity of a subject, the delivery device comprising: a delivery unit for delivering a flow entraining a substance to one nostril of a subject, the delivery unit including a nosepiece for fitting to a nostril of the subject; and a flow resistor unit for fitting to the other nostril of the subject, the flow resistor unit including a progressive resistor for progressively providing an increasing flow resistance to the delivered flow.
1 - 17 . (canceled)
18 . A nasal delivery device comprising:
a housing;
a nosepiece for fitting in a nostril of a subject, the nosepiece connected to the housing;
a substance supply unit configured to deliver a metered dose of a substance through the nosepiece;
a flow resistor; and
a trigger mechanism configured to actuate the substance supply unit upon generation of a predetermined pressure, the trigger mechanism comprising a flexible member defining a chamber within the housing in fluid communication with the nosepiece.
19 . The nasal delivery device of claim 18 , wherein the flexible member is a resilient membrane.
20 . The nasal delivery device of claim 18 , wherein the substance supply unit further comprises a biasing element and a release mechanism.
21 . The nasal delivery device of claim 20 , wherein the trigger mechanism further comprises a linkage coupling the flexible member and the release mechanism.
22 . The nasal delivery device of claim 18 , further comprising a nozzle, wherein the nozzle is fluidly connected to the substance supply unit and is configured to provide an aerosol spray through the nosepiece.
23 . The nasal delivery device of claim 18 , wherein the substance supply unit comprises a mechanical delivery pump.
24 . The nasal delivery device of claim 18 , wherein the substance is a liquid or a powder.
25 . The nasal delivery device of claim 18 , wherein the substance supply unit comprises a nebulizer.
26 . A nasal delivery device comprising:
a housing;
a nosepiece for fitting in a nostril of a subject, the nosepiece connected to the housing;
a substance supply unit configured to deliver a metered dose of a substance through the nosepiece;
a mouthpiece through which the subject exhales to actuate the substance supply unit, the mouthpiece fluidly connected to the housing;
a flow resistor; and
a trigger mechanism configured to actuate the substance supply unit upon generation of a predetermined pressure, the trigger mechanism comprising a flexible member defining a chamber within the housing in fluid communication with the nosepiece.
27 . The nasal delivery device of claim 26 , wherein the mouthpiece is in fluid communication with the chamber.
28 . The nasal delivery device of claim 26 , wherein the flexible member is a resilient membrane.
29 . The nasal delivery device of claim 26 , wherein the substance supply unit further comprises a biasing element and a release mechanism.
30 . The nasal delivery device of claim 29 , wherein the trigger mechanism further comprises a linkage coupling the flexible member and the release mechanism.
31 . The nasal delivery device of claim 26 , wherein the substance is a liquid or a powder.
32 . A nasal delivery device comprising:
a housing;
a first nosepiece for fitting in a nostril of a subject, the first nosepiece connected to the housing;
a substance supply unit configured to deliver a metered dose of a substance through the first nosepiece;
a mouthpiece through which the subject exhales to actuate the substance supply unit, the mouthpiece fluidly connected to the housing;
a flow resistor, comprising a progressive flow resistor in fluid communication with a second nosepiece; and
a trigger mechanism configured to actuate the substance supply unit upon generation of a predetermined pressure, the trigger mechanism comprising a flexible member defining a chamber within the housing in fluid communication with the first nosepiece.
33 . The nasal delivery device of claim 32 , wherein the progressive flow resistor, when inflated, indicates operation of the nasal delivery device.
34 . The nasal delivery device of claim 32 , wherein the flexible member is a resilient membrane.
35 . The nasal delivery device of claim 32 , wherein the substance supply unit further comprises a biasing element and a release mechanism.
36 . The nasal delivery device of claim 35 , wherein the trigger mechanism further comprises a linkage coupling the flexible member and the release mechanism.
37 . The nasal delivery device of claim 32 , wherein the substance is a liquid or a powder.