METHODS AND DRESSINGS FOR SEALING INTERNAL INJURIES
Disclosed are solid and frozen haemostatic materials and dressing's consisting essentially of a fibrinogen component and a fibrinogen activator. Also disclosed are methods of treating internal wounded tissue in a mammal by applying one or more of these haemostatic materials and dressings.
1 . A method for treating wounded internal tissue in a mammal comprising applying to wounded internal tissue at least one haemostatic material consisting essentially of a fibrinogen component and a fibrinogen activator for a time sufficient to join or approximate said wounded tissue and/or to reduce the flow of fluid from said wounded tissue, wherein said haemostatic material has a plurality of particles, wherein said particles each have the same composition, and wherein the moisture content of said hemostatic material is from 6% to 44%.
2 . A method for treating wounded internal tissue in a mammal comprising applying to wounded internal tissue at least one haemostatic material consisting essentially of a fibrinogen component and a fibrinogen activator for a time sufficient to join or approximate said wounded tissue and/or to reduce the flow of fluid from said wounded tissue, wherein said haemostatic material has a plurality of particles, wherein said particles each have the same composition, and wherein the moisture content of said hemostatic material is from 1% to 6%.
3 . A method for treating wounded internal tissue in a mammal comprising applying to svounded internal tissue at least one haemostatic material consisting essentially of a fibrinogen component and a fibrinogen activator for a time sufficient to join or approximate said wounded tissue and/or to reduce the flow of fluid from said wounded tissue, wherein said haemostatic material is cast or formed as a single piece.
4 . The method of claim 1 , wherein said haemostatic material includes at least one support layer.
5 . The method of claim 4 , wherein said support layer comprises a backing material.
6 . The method of claim 4 , wherein said support lay er comprises an internal support material.
7 . The method of claim 4 , wherein said support layer comprises a resorbable material.
8 . The method of claim 4 , wherein said support layer comprises a non-resorbable material.
9 . The method of claim 8 , wherein said non-resorbable material is selected from the group consisting of silicone polymers, paper, gauze, plastics, non-resorbable suture materials, and latexes.
10 . The method of claim 4 , further comprising at least one physiologically acceptable adhesive between said haemostatic material and said backing layer.
11 . The method of claim 7 , wherein saltl resorbable material is selected from the group consisting of proteinaeeous materials, carbohydrate substances and resorbable soture materials.
12 . The method of claim 11 , wherein said proteinaceous material is at least one substance selected from the group consisting of keratin, silk, fibrin, collagen, and gelatin.
13 . The method of claim 11 , wherein said carbohydrate substance is selected from the group consisting of algirtic acid and salts thereof, chitin, chitosan, cellulose, n-acetyl glucosamine, proteoglycans, glycolic acid polymers, lactic acid polymers, glycolic acid/lactic acid co-polymers, and mixtures of two or more thereof.
14 . The method of claim 1 , wherein said haemostatic material also contains a fibrin crosslinker and/or a source of calcium ions.
15 . The method of claim 1 , wherein said haemostatic material also contains one or snore of the following: at least one filler; at least one sohibilizing agent; at least one foaming agent; and at least one release agent.
16 . The method of claim 15 , wherein said filler is selected from, the group consisting of sucrose, lactose, maltose, keratin, silk, fibrin, collagen, gelatin, albumin, polysorbate, chitin, chitosan, alginic acid and salts thereof, cellulose, proteoglycans, glycolic acid polymers, lactic acid polymers, glycolic acid/lactic acid co-polymers, and mixtures of two or more thereof.
17 . The method of claim 15 , wherein said solubilizing agent is selected from the group consisting of sucrose, lactose, maltose, dextrose, mannose, trehalose, mannitol, sorbitol, albumin, sorbate, polysotbate, and mixtures of two or more thereof.
18 . The method of claim 15 , wherein said release agent is selected from the group consisting of gelatin, mannitol, sorbitol, polysorbate, sorbitan, lactose, maltose, trehalose, sorbate, glucose and mixtures of two or more thereof.
19 . The method of claim 15 , wherein said foaming agent is selected from the group consisting of mixtures of sodium bicarbonate/citric acid, sodium bicarbonate/acetic acid, calcium carbonate/citric acid and calcium carbonate/acetic acid.
20 - 44 . (canceled)