Heterocyclic amides as kinase inhibitors
Disclosed are compounds having the formula: wherein X, Y, Z 1 , Z 2 , Z 3 , Z 4 , R 5 , R A , m, A. L, and B are as defined herein, and methods of making and using the same.
1. A compound which is:
or a tautomer thereof, or a pharmaceutically acceptable salt thereof.
2. A pharmaceutical composition comprising the compound, or a tautomer thereof, or pharmaceutically acceptable salt thereof, according to claim 1 and one or more pharmaceutically acceptable excipients.
3. A method of treating ulcerative colitis comprising administering a therapeutically effective amount of the compound, or a tautomer thereof, or pharmaceutically acceptable salt thereof, according to claim 1 to a human in need thereof.
4. A method of treating Crohn's disease comprising administering a therapeutically effective amount of the compound, or a tautomer thereof, or pharmaceutically acceptable salt thereof, according to claim 1 to a human in need thereof.
5. A method of treating rheumatoid arthritis comprising administering a therapeutically effective amount of the compound, or a tautomer thereof, or pharmaceutically acceptable salt thereof, according to claim 1 to a human in need thereof.
6. A method of treating psoriasis comprising administering a therapeutically effective amount of the compound, or a tautomer thereof, or pharmaceutically acceptable salt thereof, according to claim 1 to a human in need thereof.
7. A method of treating spondyloarthritis comprising administering a therapeutically effective amount of the compound, or a tautomer thereof, or pharmaceutically acceptable salt thereof, according to claim 1 to a human in need thereof.
8. A method of treating SoJIA comprising administering a therapeutically effective amount of the compound, or a tautomer thereof, or pharmaceutically acceptable salt thereof, according to claim 1 to a human in need thereof.
9. A method of treating osteoarthritis comprising administering a therapeutically effective amount of the compound, or a tautomer thereof, or pharmaceutically acceptable salt thereof, according to claim 1 to a human in need thereof.
10. A method of treating multiple sclerosis comprising administering a therapeutically effective amount of the compound, or a tautomer thereof, or pharmaceutically acceptable salt thereof, according to claim 1 to a human in need thereof.
11. A method of treating sepsis comprising administering a therapeutically effective amount of the compound, or a tautomer thereof, or pharmaceutically acceptable salt thereof, according to claim 1 to a human in need thereof.
12. A method of treating ischemia reperfusion injury of solid organs comprising administering a therapeutically effective amount of the compound, or a tautomer thereof, or pharmaceutically acceptable salt thereof, according to claim 1 to a human in need thereof.
13. A method of treating systemic inflammatory response syndrome comprising administering a therapeutically effective amount of the compound, or a tautomer thereof, or pharmaceutically acceptable salt thereof, according to claim 1 to a human in need thereof.
14. A compound which is:
or a tautomer thereof.
15. A pharmaceutical composition comprising the compound, or a tautomer thereof, according to claim 14 and one or more pharmaceutically acceptable excipients.
16. A method of treating ulcerative colitis comprising administering a therapeutically effective amount of the compound, or a tautomer thereof, according to claim 14 to a human in need thereof.
17. A method of treating Crohn's disease comprising administering a therapeutically effective amount of the compound, or a tautomer thereof, according to claim 14 to a human in need thereof.
18. A method of treating rheumatoid arthritis comprising administering a therapeutically effective amount of the compound, or a tautomer thereof, according to claim 14 to a human in need thereof.
19. A method of treating psoriasis comprising administering a therapeutically effective amount of the compound, or a tautomer thereof, according to claim 14 to a human in need thereof.
20. A method of treating spondyloarthritis comprising administering a therapeutically effective amount of the compound, or a tautomer thereof, according to claim 14 to a human in need thereof.
21. A method of treating SoJIA comprising administering a therapeutically effective amount of the compound, or a tautomer thereof, according to claim 14 to a human in need thereof.
22. A method of treating osteoarthritis comprising administering a therapeutically effective amount of the compound, or a tautomer thereof, according to claim 14 to a human in need thereof.
23. A method of treating multiple sclerosis comprising administering a therapeutically effective amount of the compound, or a tautomer thereof, according to claim 14 to a human in need thereof.
24. A method of treating sepsis comprising administering a therapeutically effective amount of the compound, or a tautomer thereof, according to claim 14 to a human in need thereof.
25. A method of treating ischemia reperfusion injury of solid organs comprising administering a therapeutically effective amount of the compound, or a tautomer thereof, according to claim 14 to a human in need thereof.
26. A method of treating systemic inflammatory response syndrome comprising administering a therapeutically effective amount of the compound, or a tautomer thereof, according to claim 14 to a human in need thereof.