Compounds and compositions for the treatment of ocular disorders

1. A compound of Formula:

or a pharmaceutically acceptable salt thereof;

wherein:

L 1 is selected from:

L 2 is selected from:

A is selected from: H, alkyl, cycloalkyl, cycloalkylalkyl, heterocycle, heterocycloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, aryloxy, and alkyloxy;

R 1 , R 2 , and R 3 are selected from: —C(O)R 4 , C(O)A, and hydrogen wherein either R 1 or R 2 cannot be hydrogen and wherein R 1 , R 2 , and R 3 can be further optionally substituted with R 5 ;

R 4 is selected from:

(i) —C 10 -C 30 alkylR 5 , —C 10 -C 30 alkenylR 5 , —C 10 -C 30 alkynylR 5 , —C 10 -C 30 alkenylalkynylR 5 , —C 10 -C 30 alkyl, —C 10 -C 30 alkenyl, —C 10 -C 30 alkynyl, and —C 10 -C 30 alkenylalkynyl; or

(ii) an unsaturated fatty acid residue selected from linoleic acid, docosahexaenoic acid, eicosapentaenoic acid, alpha-linolenic acid, stearidonic acid, y-linolenic acid, arachidonic acid, docosatetraenoic acid, palmitoleic acid, vaccenic acid, paullinic acid, oleic acid, elaidic acid, gondoic acid, nervonic acid and mead acid; and

R 5 is selected from: halogen, hydroxyl, cyano, mercapto, amino, aryl, alkyl, alkoxy, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocycloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, aryloxy, —S(O) 2 alkyl, —S(O)alkyl, —P(O)(Oalkyl) 2 , B(OH) 2 , —Si(CH 3 ) 3 , —COOH, —COOalkyl, —CONH 2 .

2. A pharmaceutical composition comprising a compound of claim 1 in a pharmaceutically acceptable carrier.

3. The compound of claim 1 , wherein L 1 is selected from and

4. The compound of claim 1 , wherein L 2 is

wherein

R 3 is hydrogen or C(O)A; and

A is alkyl.

5. The compound of claim 1 , wherein A is selected from H, alkyl, aryloxy, aryl, and heteroaryl.

6. The compound of claim 5 , wherein A is selected from alkyl or aryloxy.

7. The compound of claim 1 , wherein R 1 and R 2 are selected from —C(O)R 4 , C(O)A, and hydrogen,

wherein

either R 1 or R 2 cannot be hydrogen; and

R 4 is defined as in claim 1 .

8. The compound of claim 7 , wherein R 4 is selected from —C 10 -C 30 alkyl, —C 10 -C 30 alkenyl, —C 10 -C 30 alkynyl, and C 10 -C 30 alkenylalkynyl.

9. The compound of claim 8 , wherein R 4 is selected from (CH 2 ) 4 (CHCHCH 2 ) 5 CH 3 and (CH 2 ) 8 CH═CH(CH 2 ) 5 CH 3 .

10. The compound of claim 1 , wherein R 4 is selected from —C 10 -C 30 alkyl, —C 10 -C 30 alkenyl, —C 10 -C 30 alkynyl, and C 10 -C 30 alkenylalkynyl.

11. The compound of claim 10 , wherein R 4 is selected from (CH 2 ) 4 (CHCHCH 2 ) 5 CH 3 and (CH 2 ) 8 CH═CH(CH 2 ) 5 CH 3 .

12. The compound of claim 3 , wherein L 2 is

wherein R 3 is hydrogen.

13. The compound of claim 12 , wherein A is alkyl, aryloxy, or aryl.

14. The compound of claim 13 , wherein A is alkyl or aryloxy.

15. The compound of claim 13 , wherein R 4 is selected from (CH 2 ) 4 (CHCHCH 2 ) 5 CH 3 and (CH 2 ) 8 CH═CH(CH 2 ) 5 CH 3 .

16. The compound of claim 15 , wherein R 1 is hydrogen and R 2 is C(O)A wherein A is defined as in claim 1 .

17. The compound of claim 16 , wherein A is alkyl or aryloxy.

18. The compound of claim 15 , wherein R 1 is C(O)A and R 2 is hydrogen wherein A is defined as in claim 1 .

19. The compound of claim 18 , wherein A is alkyl or aryloxy.

20. A compound of formula

or a pharmaceutically acceptable salt thereof.

21. The compound of claim 20 of the formula

or a pharmaceutically acceptable salt thereof.

22. The compound of claim 20 of the formula

or a pharmaceutically acceptable salt thereof.

23. The compound of claim 20 of the formula

or a pharmaceutically acceptable salt thereof.

24. A compound of formula

or a pharmaceutically acceptable salt thereof.

25. The compound of claim 24 of the formula

or a pharmaceutically acceptable salt thereof.

26. The compound of claim 24 of the formula

or a pharmaceutically acceptable salt thereof.

27. The compound of claim 24 of the formula

or a pharmaceutically acceptable salt thereof.