HYDROXYBUPROPION AND RELATED COMPOUNDS AS MODULATORS OF DRUG PLASMA LEVELS
This disclosure relates to methods administering bupropion in conjunction with dextromethorphan to a human being. Dosage forms, drug delivery systems, and methods related to dextromethorphan or dextrorphan and bupropion are also disclosed.
1 . A method of decreasing seizure risk associated with use of a bupropion comprising co-administering to a human being the bupropion with a dextromethorphan once or twice daily for at least four weeks; wherein co-administering the bupropion with the dextromethorphan results in a decreased risk of seizure while maintaining efficacy as compared administering 150 mg of the bupropion twice daily for at least four weeks without the dextromethorphan.
2 . The method of claim 1 , wherein the combination is administered twice a day.
3 . The method of claim 1 , wherein at least about 40 mg of the dextromethorphan is administered twice a day.
4 . The method of claim 1 , wherein about 50 mg to about 140 mg of the bupropion is administered twice a day.
5 . The method of claim 1 , wherein 44 mg to 46 mg of the dextromethorphan is administered twice a day.
6 . The method of claim 1 , wherein 100 mg to about 105 mg of the bupropion is administered twice a day.
7 . The method of claim 3 , wherein 100 mg to about 105 mg of the bupropion is administered twice a day.
8 . The method of claim 2 , wherein the dextromethorphan C max on the eighth day that the combination is administered, is at least about 40 ng/mL.
9 . The method of claim 1 , wherein the C max of the dextromethorphan on the eighth day is about 45 ng/mL to about 50 ng/mL.
10 . The method of claim 1 , wherein the C max of the dextromethorphan on the eighth day is about 50 ng/mL to about 60 ng/mL.
11 . The method of claim 1 , wherein the C max of the dextromethorphan on the eighth day is about 60 ng/mL to about 70 ng/mL.
12 . The method of claim 1 , wherein the C max of the dextromethorphan on the eighth day is about 70 ng/mL to about 90 ng/mL.
13 . The method of claim 7 , wherein the C max of the dextromethorphan on the eighth day is about 80 ng/mL to about 90 ng/mL.
14 . The method of claim 1 , wherein the C max of the dextromethorphan on the eighth day is about 80 ng/mL to about 100 ng/mL.
15 . The method of claim 1 , wherein the C max of the dextromethorphan on the eighth day is about 100 ng/mL to about 120 ng/mL.
16 . The method of claim 1 , wherein the C max of the dextromethorphan on the eighth day is about 120 ng/mL to about 140 ng/mL.
17 . The method of claim 1 , wherein the dextromethorphan contains deuterium.
18 . The method of claim 2 , wherein the bupropion C max on the eighth day that the combination is administered, is at least about 50 ng/mL.
19 . The method of claim 1 , wherein the C max of the bupropion on the eighth day is about 50 ng/mL to about 60 ng/mL.
20 . The method of claim 1 , wherein the C max of the bupropion on the eighth day is about 60 ng/mL to about 70 ng/mL.
21 . The method of claim 1 , wherein the C max of the bupropion on the eighth day is about 70 ng/mL to about 80 ng/mL.
22 . The method of claim 1 , wherein the C max of the bupropion on the eighth day is about 80 ng/mL to about 90 ng/mL.
23 . The method of claim 1 , wherein the C max of the bupropion on the eighth day is about 90 ng/mL to about 100 ng/mL.
24 . The method of claim 1 , wherein the C max of the bupropion on the eighth day is about 100 ng/mL to about 110 ng/mL.
25 . The method of claim 1 , wherein the C max of the bupropion on the eighth day is about 100 ng/mL to about 150 ng/mL.
26 . The method of claim 1 , wherein the bupropion contains an enantiomeric excess of R-bupropion or S-bupropion.
27 . The method of claim 2 , wherein the C max of the dextromethorphan on the first day that the combination is administered, is at least about 1.0 ng/mL.
28 . The method of claim 2 , wherein the C max of the dextromethorphan on the first day is about 1.5 ng/mL to about 20 ng/mL.
29 . The method of claim 2 , wherein the C max of the bupropion on the first day that the combination is administered, is at least about 40 ng/mL.
30 . The method of claim 2 , wherein the C max of the bupropion on the first day that is about 45 ng/mL to about 120 ng/mL.