Silica-based antimicrobial oral compositions
Oral compositions containing a carrier, a cationic antimicrobial compound, and a silica and/or silicate material are disclosed. These compositions can provide a controlled release of the antimicrobial compound.
1. An oral composition comprising:
(i) a carrier;
(ii) from about 0.02 to about 2 wt. % of a cationic antimicrobial compound; and
(iii) from about 0.5 to 3 wt. % of a silica and/or silicate material characterized by:
an average particle size in a range from about 0.1 to about 20 μm;
a CTAB surface area in a range from about 250 to about 350 m 2 /g; and
an absorptive capacity of the cationic antimicrobial compound in a range from about 200 to about 400 mg of the cationic antimicrobial compound per gram of the silica and/or silicate material.
2. The composition of claim 1 , wherein:
the silica and/or silicate material comprises a precipitated silica having an absorptive capacity of the cationic antimicrobial compound in a range from about 210 to about 325 mg/g; and
the cationic antimicrobial compound comprises an antimicrobial quaternary ammonium compound.
3. The composition of claim 1 , wherein the silica and/or silicate material comprises an alkali metal aluminosilicate characterized by:
an average particle size in a range from about 0.5 μm to about 10 μm;
a CTAB surface area in a range from about 250 m 2 /g to about 350 m 2 /g; and
a BET surface area in a range from about 200 m 2 /g to about 800 m 2 /g.
4. The composition of claim 1 , wherein the silica and/or silicate material comprises a precipitated silica characterized by:
an average particle size in a range from about 0.5 μm to about 6 μm; and
a BET surface area in a range from about 250 m 2 /g to about 700 m 2 /g.
5. The composition of claim 4 , wherein the cationic antimicrobial compound comprises cetylpyridinium chloride (CPC).
6. The composition of claim 1 , wherein:
the carrier comprises water; and
the composition comprises from about 0.1 to about 1 wt. % of the cationic antimicrobial compound and from about 0.5 to 3 wt. % of the silica and/or silicate material.
7. The composition of claim 1 , wherein:
the carrier comprises a dentifrice composition; and
the oral composition comprises from about 0.1 to about 1 wt. % of the cationic antimicrobial compound and from about 0.5 to 3 wt. % of the silica and/or silicate material.
8. The composition of claim 1 , wherein the composition is in the form of a mouthwash, a mouth rinse, a mouth spray, a chewing gum, a breath strip, a lozenge, a candy, a tablet, a mint, a toothpaste, a gel, an edible film, or a whitening strip.
9. The composition of claim 1 , wherein the composition further comprises an additive comprising a humectant, a binder, a flavoring agent, an anti-cavity agent, a colorant, a sweetener, a surfactant, a thickener, a preservative, or combinations thereof.
10. The composition of claim 1 , wherein the composition further comprises an abrasive silica material characterized by:
a CTAB surface area in a range from about 1 to about 60 m 2 /g; and
an absorptive capacity of the cationic antimicrobial compound in a range from about 2 to about 100 mg of the cationic antimicrobial compound per gram of the abrasive silica material.
11. The composition of claim 10 , wherein the composition comprises from about 5 to about 25 wt. % of the abrasive silica material.
12. A method of reducing or inhibiting microbial growth in an oral cavity of a subject, the method comprising administering an effective amount of the composition of claim 1 to the oral cavity of the subject.
13. The method of claim 12 , wherein:
the subject is a human; and
the effective amount is in a range from about 0.25 to about 25 grams.
14. The method of claim 12 , wherein:
the subject is a human; and
the effective amount is an amount sufficient for a controlled release of at least 1 ppm of the cationic antimicrobial compound for a controlled release time period in a range from about 15 min to about 12 hr.
15. An oral composition comprising:
(a) a carrier; and
(b) from about 0.5 to 4.5 wt. % of treated particles comprising:
(I) a silica and/or silicate material; and
(II) 0.1 to 1 wt. % of a cationic antimicrobial compound comprising cetylpyridinium chloride; wherein:
the silica and/or silicate material has an absorptive capacity of the cationic antimicrobial compound in a range from about 200 to about 400 mg of the cationic antimicrobial compound per gram of the silica and/or silicate material; and
the treated particles comprise the cationic antimicrobial compound at an amount in a range from about 50% to about 200% of the absorptive capacity; and
the silica and/or silicate material is characterized by:
an average particle size in a range from about 0.5 μm to about 6 μm;
a CTAB surface area in a range from about 250 m 2 /g to about 350 m 2 /g; and
a BET surface area in a range from about 250 m 2 /g to about 700 m 2 /g.
16. The composition of claim 15 , wherein the treated particles comprise the cationic antimicrobial compound at an amount in a range from about 75% to about 150% of the absorptive capacity.
17. The composition of claim 15 , wherein:
the silica and/or silicate material comprises a precipitated silica having an absorptive capacity of the cationic antimicrobial compound in a range from about 210 to about 325 mg/g; and
the composition comprises from about 1 to 3 wt. % of the precipitated silica.
18. The composition of claim 15 , wherein the composition further comprises from about 5 to about 15 wt. % of an abrasive silica material characterized by:
a CTAB surface area in a range from about 1 to about 35 m 2 /g; and
an absorptive capacity of the cationic antimicrobial compound in a range from about 5 to about 40 mg of the cationic antimicrobial compound per gram of the abrasive silica material.
19. A method of reducing or inhibiting microbial growth in an oral cavity of a subject, the method comprising administering an effective amount of the composition of claim 15 to the oral cavity of the subject; wherein:
the effective amount is in a range from about 0.25 to about 25 grams; and/or
the effective amount is an amount sufficient for a controlled release of at least 1 ppm of the cationic antimicrobial compound for a controlled release time period in a range from about 30 min to about 8 hr.
20. The composition of claim 1 , wherein said composition is capable of providing a controlled release of at least 1 ppm of the cationic antimicrobial compound for a controlled release time period in a range from about 15 min to about 12 hr.
21. The composition of claim 20 , wherein the composition, when the antimicrobial compound is cetylpyridinium chloride and such composition is administered to the oral cavity of a subject, achieves a controlled release of greater or equal to two times the MIC of 1 ppm of the cetylpyridinium chloride for all nineteen washes.