Devices and methods for closure of transvascular or transcameral access ports

1. An axially telescoping prosthesis comprising:

a) a plurality of discrete radially expandable braided mesh bodies, each of said bodies being formed from a plurality of filaments that can slide across one another, each of the braided mesh bodies being configured to self-expand into at least one disc, each radially expandable braided mesh body defining a volume therein, the plurality of mesh bodies being axially displaceable with respect to one another; and

b) a resilient member structurally distinct from the plurality of discrete mesh bodies, the resilient member being attached to and arranged to pass through a central region of the mesh bodies, the resilient member being configured and arranged to attach the plurality of discrete radially expandable braided mesh bodies to each other, wherein: (i) the radially expandable braided mesh bodies are selectively telescopically displaceable from one another along a central longitudinal axis of the prosthesis by stretching or relaxing the resilient member to accommodate differently sized anatomies, (ii) the resilient member is substantially co-axial with the central longitudinal axis of the prosthesis, and (iii) the resilient member is configured to cause the prosthesis to shorten along the axis and expand radially when the resilient member is relaxed.

2. The prosthesis of claim 1 , further comprising at least one length limiting tether attaching the plurality of discrete radially expandable braided mesh bodies to each other, the at least one length limiting tether acting to prevent the resilient member from elongating beyond a predetermined length.

3. The prosthesis of claim 1 , further comprising (i) at least one fabric disc disposed within each of the radially expandable mesh bodies; and (ii) a tubular fabric portion attached to at least one of the fabric discs, the tubular fabric portion extending proximally into a neck region of the prosthesis.

4. The prosthesis of claim 1 , wherein the resilient member is a coil spring surrounded by fabric that causes the prosthesis to collapse axially and the radially expandable braided mesh bodies to expand radially and is configured to prevent the prosthesis from being pulled axially through an anatomical opening it has been delivered through after it has been deployed, and further wherein a neck region of the prosthesis spanning between the radially expandable braided mesh bodies including the coil spring surrounded by the fabric expands radially outwardly when the coil spring is unconstrained to help achieve hemostasis.

5. The prosthesis of claim 1 , wherein the resilient member is a tension coil spring.

6. The prosthesis of claim 1 , wherein the prosthesis defines a lumen along its length through the plurality of discrete radially expandable braided mesh bodies along an axial centerline of the prosthesis, the lumen being configured and arranged to act as an adjustable shunt having an adjustable length when the prosthesis is deployed to connect two lumens.

7. The prosthesis of claim 1 , wherein the prosthesis is configured to seal at least one hole in one lumen.

8. A system for delivering a prosthesis according to claim 1 , comprising:

a) an outer tubular sheath having a proximal end and a distal end and defining a first lumen therethrough along at least a portion of its length;

b) an intermediate tubular member disposed at least partially within the first lumen and being slidably disposed with respect to the outer tubular sheath, the intermediate tubular member having a proximal end, a distal end, and, a flexible distal portion configured to be protrudable distally beyond the distal end of the outer tubular sheath, the intermediate tubular member defining a second lumen therethrough along at least a part of its length;

c) an inner elongate member being disposed at least partially within the second lumen, the inner elongate member being slidably disposed with respect to the intermediate tubular member, the inner elongate member having a proximal end and a distal end configured to be displaced distally beyond the distal end of the intermediate tubular member; and

d) a prosthesis according to claim 1 removably mounted on the distal end of the intermediate tubular member, wherein the prosthesis can be longitudinally stretched by advancing the inner elongate member distally with respect to the intermediate tubular member and against an inner face of an end region of the prosthesis, and further wherein said longitudinal stretch of said prosthesis causes the prosthesis to collapse radially inwardly to permit said prosthesis to be withdrawn into said distal end of said outer tubular sheath.

9. The system of claim 8 , wherein the distal end of the outer tubular member is cut at an angle that is oblique with respect to a central axis defined by the system.

10. The system of claim 9 , wherein the distal end further includes a radiopaque marker proximate the distal end making the angle at which the distal end is cut being visible under fluoroscopy to help reduce canting of the prosthesis during implantation.

11. The system of claim 8 , wherein the flexible of distal portion of the intermediate tubular member is configured and adapted to permit the intermediate tubular member to be deformed into a reverse curved geometry with respect to a central axis of a proximal portion of the delivery system while inside a patient's lumen.

12. The system of claim 8 , wherein the inner elongate member is a tubular member configured to permit a guidewire to pass therethrough.

13. The system of claim 12 , wherein the distal end of the inner elongate member is configured to abut against the inner face of the end region of the prosthesis to form a guidewire lumen to permit the guidewire passing through the inner elongate member to pass through a distal face of the prosthesis.