Method of diagnosis and treatment of tumors using high intensity focused ultrasound
A method of diagnosis and treatment of tumors using High Intensity Focused Ultrasound is provided. The method of diagnosing the presence of a tumor in a patient comprises the steps of subjecting a tumor to high intensity focused ultrasound (HIFU) to cause the tumor cells to release cellular material and evaluating the cellular material for a tumor marker. The method of treating a tumor in a patient can also comprise the step of subjecting a tumor to high intensity focused ultrasound (HIFU) to provoke an immune response.
1. A method of inhibiting tumor growth in a patient, the method comprising a step of subjecting a tumor of the patient to low energy, high intensity focused ultrasound (LO-HIFU) followed after 1-7 days by a step of subjecting the tumor to high energy, high intensity focused ultrasound (HI-HIFU) in an amount effective to inhibit tumor growth in a patient, wherein the step of subjecting the tumor of the patient to LO-HIFU followed by the step of subjecting the tumor to HI-HIFU is more effective in inhibiting tumor growth than administration of either LO-HIFU alone or HI-HIFU alone.
2. The method of claim 1 , wherein HI-HIFU is administered to the patient 1-2 days after administration of LO-HIFU.
3. The method of claim 1 , wherein HI-HIFU applies power in the amount of about 1.3 to 2.0 KW per cm 2 .
4. The method of claim 1 , wherein HI-HIFU has an operating frequency of about 1.0 to 5.0 MHz.
5. The method of claim 1 , wherein HI-HIFU has an operating frequency greater than about 20 KHz and less than about 100 MHz.
6. The method of claim 1 , wherein LO-HIFU applies power in the amount of about 0.5 KW per cm 2 .
7. The method of claim 1 , wherein LO-HIFU applies energy in the amount of about 0.01 to 3.0 KW-seconds per cm 2 .
8. The method of claim 1 , wherein LO-HIFU operates with a pulse having a duration of about 0.01 to 1.0 seconds with pulse repetition frequencies of about 0.5 to 5.0 Hz.
9. The method of claim 1 , wherein LO-HIFU operates with repetition frequencies of about 0.5 to 30.0 Hz.
10. The method of claim 1 , wherein HI-HIFU operates with repetition frequencies of about 0.5 to 30.0 Hz.
11. The method of claim 1 , wherein LO-HIFU is administered at a dose that LO-HIFU treatment, in the absence of HI-HIFU treatment, is ineffective in inhibiting tumor growth, and wherein the step of subjecting the tumor of the patient to LO-HIFU followed by the step of subjecting the tumor to HI-HIFU is more effective in inhibiting tumor growth than administration of HI-HIFU alone.