Blood sampling, storage and treatment apparatus
Systems and methods for collecting blood and other liquid samples. A sample holder may include a cap and porous element arranged to receive a blood or other liquid sample. The porous element may be stored in a sealed container, e.g., immediately after blood sample collection, and the sample dried while sealed in the container.
1. A sample holder, comprising:
a cap arranged to engage with and close an opening of at least one vessel, the cap having a top and a bottom, and a gripping surface between the top and bottom;
a porous element attached to the bottom of the cap and extending away from the bottom of the cap, the porous element arranged to absorb a blood sample including blood serum and other blood-borne materials having a size smaller than a threshold by wicking the blood serum into the porous element; and
a blotter element attached to the porous element and arranged to contact blood and wick blood serum and other blood-borne materials having a size smaller than the threshold to the porous element, the blotter element arranged to retain whole blood cells and other blood-borne materials having a size greater than the threshold in the blotter element such that the porous element absorbs only blood serum including any other blood-borne materials having a size smaller than the threshold.
2. The sample holder of claim 1 , wherein the blotter element is separable from the porous element.
3. The sample holder of claim 1 , wherein the blotter element is arranged to absorb up to 20 microliters of blood.
4. The sample holder of claim 1 , further comprising a container having an internal space constructed and arranged to receive the cap, porous element and blotter element into the internal space, the container including a cover arranged to enclose the cap, porous element and blotter element in the internal space.
5. The sample holder of claim 4 , wherein the internal space of the container is constructed and arranged to dry a blood sample held by the porous element and the blotter element with the porous element and the blotter element enclosed in the internal space.
6. The sample holder of claim 1 , wherein the cap includes an identifying indicia that is inseparable from the cap and is attached to the cap prior to a blood sample being held by the porous element and the blotter element.
7. The sample holder of claim 6 , wherein the cap includes an engagement feature to engage with a first vessel.
8. The sample holder of claim 7 , further comprising the first vessel arranged to receive the porous element and the blotter element in a volume of the first vessel and to engage with the engagement feature of the cap to seal the porous element and the blotter element in the volume.
9. The sample holder of claim 8 , wherein the first vessel is arranged to hold the porous element and the blotter element and a sample liquid during acoustic energy treatment of a blood sample held by the porous element and the blotter element employed to recover biomolecules in the blood sample.
10. The sample holder of claim 4 , wherein the container includes a desiccant to receive moisture from blood in the porous element and the blotter element to dry the blood.
11. The sample holder of claim 10 , wherein the container is arranged to hold a plurality of cap and porous element and blotter element assemblies.
12. The sample holder of claim 10 , wherein the container and cover are arranged to enclose the cap, porous element and blotter element having an undried blood sample in a sealed space such that the desiccant receives moisture to dry the blood sample.
13. The sample holder of claim 1 , wherein the porous element has a rod shape and is formed as a porous polymer fiber.