Farnesoid X receptor modulators
The present application provides a compound of formula I: or a pharmaceutically acceptable salt, solvate, or amino acid conjugate thereof, wherein R 1 -R 10 , m, n, p, and are as described herein. The present invention relates generally to FXR modulators and to methods of making and using said compounds.
1. A compound selected from:
or a pharmaceutically acceptable salt or solvate thereof.
2. A pharmaceutical composition comprising the compound of claim 1 or a pharmaceutically acceptable salt or solvate thereof and a pharmaceutically acceptable carrier or excipient.
3. The compound of claim 1 , which is
or a pharmaceutically acceptable salt or solvate thereof.
4. The compound of claim 3 , which is
or a pharmaceutically acceptable salt thereof.
5. The compound of claim 3 , which is
6. The compound of claim 1 , which is
or a pharmaceutically acceptable salt or solvate thereof.
7. The compound of claim 6 , which is
or a pharmaceutically acceptable salt thereof.
8. The compound of claim 6 , which is
9. A pharmaceutical composition comprising the compound of claim 3 or a pharmaceutically acceptable salt or solvate thereof and a pharmaceutically acceptable carrier or excipient.
10. A pharmaceutical composition comprising the compound of claim 6 or a pharmaceutically acceptable salt or solvate thereof and a pharmaceutically acceptable carrier or excipient.