Methods and systems for treating hydrocephalus
Methods for treating hydrocephalus using a shunt, the shunt having one or more CSF intake openings in a distal portion, a valve disposed in a proximal portion of the shunt, and a lumen extending between the one or more CSF intake openings and the valve, the method comprises deploying the shunt in a body of a patient so that the distal portion of the shunt is at least partially disposed within a CP angle cistern, a body of the shunt is at least partially disposed within an IPS of the patient, and the proximal portion of the shunt is at least partially disposed within or proximate to a JV of the patient, wherein, after deployment of the shunt, CSF flows from the CP angle cistern to the JV via the shunt lumen at a flow rate in a range of 5 ml per hour to 15 ml per hour.
1. A method for treating hydrocephalus, comprising:
deploying a shunt in a body of a hydrocephalus patient so that a distal portion of the shunt is at least partially disposed within a cerebellopontine (CP) angle cistern of the patient, a body of the shunt is at least partially disposed within an inferior petrosal sinus (IPS) of the patient, and a proximal portion of the shunt is at least partially disposed within, or proximate to, a jugular vein (JV) of the patient,
wherein, after deployment of the shunt, cerebrospinal fluid (CSF) flows from the patient's CP angle cistern into the patient's JV via the shunt.
2. The method of claim 1 , wherein the hydrocephalus being treated is normal pressure hydrocephalus.
3. The method of claim 1 ,
the distal portion of the deployed shunt comprising one or more CSF intake openings positioned within the patient's CP angle cistern, and
the proximal portion of the deployed shunt comprising a CSF outflow opening disposed within, or proximate to, the patient's JV,
wherein the shunt comprises a lumen extending between the one or more CSF intake openings and the CSF outflow opening, and a valve interposed in the shunt lumen between the one or more CSF fluid intake openings and the CSF outflow opening,
wherein the valve is configured to maintain a CSF flow rate of 5 ml to 15 ml per hour at a pressure differential between the patient's CP angle cistern and the patient's JV in a range of 3 mm Hg to 5 mm Hg.
4. The method of claim 3 , the shunt lumen having an inner diameter in a range of 0.002″ to 0.020″.
5. The method of claim 1 , wherein, after deployment of the shunt, a spring-like body of the deployed shunt applies a tensional force between the proximal and distal portions of the shunt.
6. The method of claim 1 , wherein deploying the shunt comprises introducing the shunt percutaneously through a venous access location in the patient.
7. The method of claim 1 , wherein deploying the shunt comprises advancing the distal portion of the shunt from the patient's IPS into the patient's CP angle cistern using a tissue penetrating member.
8. The method of claim 7 , wherein the tissue penetrating member is coupled to a distal end of the shunt, and wherein advancing the distal portion of the shunt from the patient's IPS into the patient's CP angle cistern comprises advancing the tissue penetrating member and distal portion of the shunt through a dura mater tissue wall of the IPS, and through an arachnoid tissue layer, respectively, into the CP angle cistern.
9. The method of claim 7 , wherein during advancement of the distal portion of the shunt, the distal portion of the shunt is at least partially disposed in a delivery lumen of a delivery catheter, the tissue penetrating member comprising a tissue penetrating tip of the delivery catheter, and wherein advancing the distal portion of the shunt from the patient's IPS into the patient's CP angle cistern comprises advancing the delivery catheter so that the tissue penetrating tip penetrates through a dura mater tissue wall of the IPS, and through an arachnoid tissue layer, respectively, into the CP angle cistern.
10. The method of claim 1 , wherein deploying the shunt comprises introducing the shunt into the patient's body while the shunt is at least partially disposed in a delivery catheter that is advanced over a guidewire extending through a lumen of the delivery catheter, which may be a same or different lumen in which the shunt is at least partially disposed, until a distal portion of the delivery catheter is positioned in the IPS.
11. The method of claim 1 , further comprising imaging the shunt while deploying the shunt in the patient's body.
12. The method of claim 1 , wherein the distal portion of the deployed shunt comprises one or more CSF intake openings in fluid communication with the patient's CP angle cistern, and a distal anchoring mechanism that maintains the one or more CSF intake openings separated, apart and/or directed away from an arachnoid layer of the CP angle cistern.
13. The method of claim 1 , wherein the proximal portion of the shunt comprises a proximal anchoring mechanism that maintains a CSF outflow opening disposed in the proximal portion of the shunt separated, apart, and/or directed away from a wall of the patient's JV.
14. A method for treating hydrocephalus, comprising:
introducing a shunt percutaneously through a venous access location in a hydrocephalus patient's body; and
deploying the shunt so that one or more cerebrospinal fluid (CSF) intake openings located in a distal portion of the shunt are positioned within a cerebellopontine (CP) angle cistern of the patient, a body of the shunt is at least partially disposed within an inferior petrosal sinus (IPS) of the patient, and a CSF outflow opening located in a proximal portion of the shunt is disposed within, or proximate to, a jugular vein (JV) of the patient,
the shunt comprising a lumen extending between the one or more CSF intake openings and the CSF outflow opening,
such that, after deployment of the shunt, cerebrospinal fluid (CSF) flows from the patient's CP angle cistern to the patient's JV via the shunt lumen.
15. The method of claim 14 , wherein the hydrocephalus being treated is normal pressure hydrocephalus, the shunt further comprising a valve interposed in the shunt lumen between the one or more CSF intake openings and the CSF outflow opening, wherein the valve is configured to maintain a flow rate of 5 ml to 15 ml per hour at a pressure differential between the patient's CP angle cistern and the patient's JV in a range of 3 mm Hg to 5 mm Hg.
16. The method of claim 14 , wherein the distal portion of the deployed shunt comprises a distal anchoring mechanism that maintains the one or more CSF intake openings separated, apart and/or directed away from an arachnoid layer of the CP angle cistern.
17. The method of claim 14 , wherein the proximal portion of the deployed shunt comprises a proximal anchoring mechanism that maintains the CSF outflow opening separated, apart, and/or directed away from a wall of the patient's JV.
18. A method for treating normal pressure hydrocephalus (NPH), comprising:
introducing a shunt percutaneously through a venous access location in an NPH patient's body; and
deploying the shunt so that a distal portion of the shunt is at least partially disposed within a cerebellopontine (CP) angle cistern of the patient, a body of the shunt is at least partially disposed within an inferior petrosal sinus (IPS) of the patient, and a proximal portion of the shunt is at least partially disposed within, or proximate to, a jugular vein (JV) of the patient,
wherein, after deployment of the shunt, cerebrospinal fluid (CSF) flows from the patient's CP angle cistern into the patient's JV via the shunt.
19. The method of claim 18 , further comprising imaging the shunt while deploying the shunt in the patient's body.
20. The method of claim 18 ,
the distal portion of the deployed shunt comprising one or more CSF intake openings positioned within the patient's CP angle cistern, and
the proximal portion of the deployed shunt comprising a CSF outflow opening disposed within, or proximate to, the patient's JV,
wherein the shunt comprises a lumen extending between the one or more CSF intake openings and the CSF outflow opening, and a valve interposed in the shunt lumen between the one or more CSF fluid intake openings and the CSF outflow opening,
wherein the valve is configured to maintain a CSF flow rate of 5 ml to 15 ml per hour at a pressure differential between the patient's CP angle cistern and the patient's JV in a range of 3 mm Hg to 5 mm Hg.