Calibration and detection of silicone oil in syringe barrels
Medical syringe barrels having the inner surface coated with cured silicone oil are used for calibration and detection of silicone oil in medical syringe barrels. Calibration standards as provided in this invention allow for quick determination how well a lubrication system for lubricating medical syringe barrels with silicone oil is working.
1. A method of calibration and detection of silicone oil in syringe barrels, comprising:
(a) providing a syringe barrel which has the inner surface coated with a silicone oil;
(b) obtaining an image with an imaging system of the inner surface of the syringe barrel coated with the silicone oil, wherein the imaging system is capable of detecting silicone oil;
(c) determining with a computer image analysis program executed by a computer a distribution pattern of the silicone oil at the inner surface from the obtained image;
(d) determining by the computer image analysis program executed by the computer a comparison between (i) the distribution pattern of the silicone oil at the inner surface of the syringe barrel, with (ii) a calibration distribution pattern of an inner surface of a calibration syringe barrel coated with a cured silicone oil, wherein the silicone oil in the cured silicone oil is the same silicone oil as in the syringe barrel, wherein the calibration distribution pattern of the cured silicone oil is obtained from a calibration image obtained with the imaging system of the inner surface of calibration syringe barrel; and
(e) outputting the comparison by the computer image analysis program executed by the computer.
2. The method as set forth in claim 1 , wherein the cured silicone oil is chemically doped with a fluorescent material or a fluorescent tag that can be dissolved in silicone oil.
3. The method as set forth in claim 1 , wherein the cured silicone oil is chemically or physically doped with a hydrophobic quantum dot.
4. The method as set forth in claim 1 , wherein the cured silicone oil is a curable Polydimethylsiloxane (PDMS).
5. The method as set forth in claim 1 , wherein the outputting the comparison comprises heatmaps.
6. A system for calibration and detection of silicone oil in syringe barrels, comprising:
(a) a syringe barrel which has the inner surface coated with a silicone oil;
(b) an imaging system capable of obtaining an image and detecting silicone oil of the inner surface of the syringe barrel;
(c) a computer image analysis program executed by a computer to analyze a distribution pattern of the silicone oil at the inner surface from the obtained image;
(d) the computer image analysis program executed by a computer capable of determining a comparison between (i) the distribution pattern of the silicone oil at the inner surface of the syringe barrel, with (ii) a calibration distribution pattern of an inner surface of a calibration syringe barrel coated with a cured silicone oil, wherein the silicone oil in the cured silicone oil is the same silicone oil as in the syringe barrel, wherein the calibration distribution pattern of the cured silicone oil is obtained from a calibration image obtained with the imaging system of the inner surface of calibration syringe barrel; and
(e) the computer image analysis program executed by a computer capable of outputting the comparison.
7. The system as set forth in claim 6 , wherein the cured silicone oil is chemically doped with a fluorescent material or a fluorescent tag that can be dissolved in silicone oil.
8. The system as set forth in claim 6 , wherein the cured silicone oil is chemically or physically doped with a hydrophobic quantum dot.
9. The system as set forth in claim 6 , wherein the cured silicone oil is a curable Polydimethylsiloxane (PDMS).
10. The system as set forth in claim 6 , wherein the outputting the comparison comprises heatmaps.
11. A calibration syringe barrel, comprising: a syringe barrel wherein the inner surface of the syringe barrel is coated with a cured silicone oil, wherein the cured silicone oil defines a reference silicone oil distribution pattern, wherein the reference silicone oil distribution pattern is useful as a reference pattern for a silicone oil distribution pattern of other syringe barrels which have the inner surface coated with silicone oil, and wherein the silicone oil in the cured silicone oil is the same silicone oil as in the other syringe barrels.