IP Library › Granted Patent US 10,144,942
Granted Patent B2
US 10,144,942 · App. 15/294,249 · Granted Dec 4, 2018

Modification of RNA-related enzymes for enhanced production

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Quick Facts
Patent No.
US 10,144,942
App. No.
15/294,249
Granted
Dec 4, 2018
Kind
B2
Abstract

The present invention provides, among other things, methods and compositions for large-scale production of capped mRNA using SUMO-Guanylyl Transferase fusion protein.

Claims (1)

1. A method of producing a capped RNA or RNA analog oligonucleotide, comprising transferring and methylating a guanylyl molecule to the 5′ end of the RNA or RNA analog oligonucleotide using a SUMO fusion guanylyl transferase comprising SEQ ID NO: 8 and SEQ ID NO: 7.

Assignments (3)
CHANGE OF NAME Recorded Jul 20, 2017
From: RANA THERAPEUTICS, INC.
To: TRANSLATE BIO, INC.
Reel/Frame 043267/0165 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 6, 2017
From: SHIRE HUMAN GENETIC THERAPIES, INC.
To: RANA THERAPEUTICS, INC.
Reel/Frame 042177/0032 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 15, 2016
From: STRACK-LOGUE, BETTINA; DEROSA, FRANK; HEARTLEIN, MICHAEL
To: SHIRE HUMAN GENETIC THERAPIES, INC.
Reel/Frame 040740/0042 →