Asymmetric auxiliary group
To provide a chiral reagent or a salt thereof. The chiral reagent has following chemical formula (I). In the formula (I), G 1 and G 2 are independently a hydrogen atom, a nitro group (—NO 2 ), a halogen atom, a cyano group (—CN), a group of formula (II) or (III), or both G 1 and G 2 taken together to form a group of formula (IV).
1. A chiral reagent or a salt thereof, wherein the chiral reagent has the structure of the following chemical formula (I′):
wherein G 1 is a hydrogen atom, a nitro group, a halogen atom, a cyano group, or a group of formula (II), (III) or (V), G 2 is a nitro group, a cyano group, or a group of formula (III) or (V), or both G 1 and G 2 are taken together to form a group of formula (IV),
wherein G 21 to G 23 are independently a hydrogen atom, a nitro group, a halogen atom, a cyano group or C 1-3 alkyl group,
wherein G 31 to G 33 are independently C 1-4 alkyl group, C 1-4 alkoxy group, C 6-14 aryl group, C 7-14 aralkyl group, C 1-4 alkyl C 6-14 aryl group, C 1-4 alkoxy C 6-14 aryl group, or C 6-14 aryl C 1-4 alkyl group,
wherein G 41 to G 46 are independently a hydrogen atom, a nitro group, a halogen atom, a cyano group or C 1-3 alkyl group,
wherein G 51 to G 53 are independently a hydrogen atom, a nitro group, a halogen atom, a cyano group, C 1-3 alkyl group or C 1-3 alkyloxy group.
2. The chiral reagent or a salt thereof in accordance with claim 1 , wherein G 1 is a hydrogen atom.
3. The chiral reagent or a salt thereof in accordance with claim 1 , wherein G 1 is a nitro group.
4. The chiral reagent or a salt thereof in accordance with claim 1 , wherein G 1 is a halogen atom.
5. The chiral reagent or a salt thereof in accordance with claim 1 , wherein G 1 is a cyano group.
6. The chiral reagent or a salt thereof in accordance with claim 1 , wherein G 1 is a group of formula (II).
7. The chiral reagent or a salt thereof in accordance with claim 1 , wherein G 1 is a group of formula (III).
8. The chiral reagent or a salt thereof in accordance with claim 1 , wherein G 1 is a group of formula (V).
9. The chiral reagent or a salt thereof in accordance with claim 1 , wherein G 2 is a nitro group.
10. The chiral reagent or a salt thereof in accordance with claim 1 , wherein G 2 is a cyano group.
11. The chiral reagent or a salt thereof in accordance with claim 1 , wherein G 2 is a group of formula (III).
12. The chiral reagent or a salt thereof in accordance with claim 1 , wherein G 2 is a group of formula (III), wherein G 31 to G 33 are independently C 1-4 alkyl group, C 6-14 aryl group, C 7-14 aralkyl group, C 1-4 alkyl C 6-14 aryl group, C 1-4 alkoxy C 6-14 aryl group, or C 6-14 aryl C 1-4 alkyl group.
13. The chiral reagent or a salt thereof in accordance with claim 1 , wherein G 2 is a group of formula (III), wherein G 31 to G 33 are independently C 1-4 alkyl group, C 6 aryl group, C 7-10 aralkyl group, C 1-4 alkyl C 6 aryl group, C 1-4 alkoxy C 6 aryl group, or C 6 aryl C 1-4 alkyl group.
14. The chiral reagent or a salt thereof in accordance with claim 1 , wherein G 2 is a group of formula (III), wherein G 31 to G 33 are independently C 1-4 alkyl group, or C 6 aryl group.
15. The chiral reagent or a salt thereof in accordance with claim 1 , wherein G 2 is a group of formula (III), wherein G 31 to G 33 are independently C 1-4 alkyl group.
16. The chiral reagent or a salt thereof in accordance with claim 1 , wherein G 2 is a group of formula (III), wherein G 31 and G 33 are C 6 aryl group and G 32 is C 1-4 alkyl group.
17. The chiral reagent or a salt thereof in accordance with claim 1 , wherein G 2 is a group of formula (V).
18. The chiral reagent or a salt thereof in accordance with claim 1 , wherein G 2 is a group of formula (V), wherein each of G 51 and G 52 is a hydrogen atom and G 53 is a 4-methyl group.
19. A compound having the structure of
or a salt thereof.
20. A compound having the structure of
or a salt thereof.