IP Library › Granted Patent US 10,039,737
Granted Patent B2
US 10,039,737 · App. 15/296,414 · Granted Aug 7, 2018

Multi-arm polymeric alkanoate conjugates

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Quick Facts
Patent No.
US 10,039,737
App. No.
15/296,414
Granted
Aug 7, 2018
Kind
B2
Abstract

Among other aspects, provided herein are multi-armed polymer conjugates comprising an alkanoate-linker, compositions comprising such conjugates, and related methods of making and administering the same. Methods of treatment employing such conjugates and related uses are also provided. The conjugates are prepared with high drug loading efficiencies.

Claims (3)

1. A multi-arm polymer-docetaxel conjugate selected from the group consisting of

where DOC is docetaxel, having a structure:

2. A pharmaceutical composition comprising the multi-arm polymer-docetaxel conjugate of claim 1 and a pharmaceutically acceptable carrier.

Assignments (2)
RELEASE OF SECURITY INTEREST Recorded Apr 17, 2020
From: TC LENDING, LLC, AS COLLATERAL AGENT
To: NEKTAR THERAPEUTICS
Reel/Frame 053180/0009 →
SECURITY INTEREST Recorded Jan 3, 2017
From: NEKTAR THERAPEUTICS
To: TC LENDING, LLC, AS COLLATERAL AGENT
Reel/Frame 040828/0882 →