Fixed Dose Combination for Pain Relief Without Edema
Compositions and methods for individualized therapy of pain using a non-steroidal anti-inflammatory drug (NSAID) and an anti-hypertensive without inducing intolerable edema. Said methods comprise basing NSAID/anti-hypertensive dose on each patient's pharmacokinetic response to said NSAID.
1 - 23 . (canceled)
24 . A method for treating pain in a mammal, comprising:
a. administering or causing to be administered to the mammal celecoxib and lisinopril in a single dosage formulation;
b. administering the celecoxib and lisinopril to the mammal for a period time sufficient to treat the pain, but not less than sixty (60) days;
wherein, the treatment reduces the incidence of edema in the mammal administered celecoxib and lisinopril as compared to a mammal administered celecoxib alone by at least 17%.
25 . The method of claim 24 , wherein the pain is arthritic pain.
26 . The method of claim 25 , wherein the arthritic pain is osteoarthritic pain.
27 . The method of claim 24 , wherein the composition is a “fixed dose combination” (FDC) in the form of pill in pill, capsule in capsule, bilayer tablet or other formulation method with physical separation between celecoxib and lisinopril.
28 . The method of claim 24 , wherein the composition following administration reduces the incidence of edema in a mammal when compared to a mammal administered celecoxib alone.
29 . The method of claim 24 , wherein the dose of celecoxib is 50 to 400 mg.
30 . The method of claim 24 , where the dose of lisinopril is 2.5 to 100 mg.
31 . The method of claim 24 , wherein the celecoxib and lisinopril is administered to the mammal orally, rectally, by inhalation, trans-cutaneously, by injection, intravenously or intraarterially.
32 . The method of claim 24 , wherein the celecoxib and lisinopril is provided to the mammal in the form of a tablet, a capsule, a sachet, an orally disintegrating film, a wafter or a long lasting injectable system.
33 . The method of claim 24 , wherein the celecoxib and lisinopril are administered to the mammal in the form of a capsule, a pill, or a bilayer.
34 . The method of claim 33 , wherein the pill is in the form a pill in a pill.
35 . The method of claim 33 , wherein the capsule is in the form of a capsule in a capsule.
36 . The method of claim 33 , wherein the capsule, the pill, or the bilayer contain an enteric coating.
37 . The method of claim 24 , wherein the dose of celecoxib and lisinopril in a single dosage unit is 100 mg celecoxib and 40 mg lisinopril, 200 mg and celecoxib 40 mg lisinopril, 100 mg celecoxib and 5 mg lisinopril, or 200 mg celecoxib and 5 mg lisinopril.
38 . The method of claim 24 , wherein the pain control for the mammal is adequate.
39 . A method for treating osteoarthritic pain in a mammal, comprising:
a. administering or causing to be administered to the mammal celecoxib and lisinopril in a single dosage formulation;
b. administering the celecoxib and lisinopril to the mammal for a period time sufficient to treat the pain, but not less than sixty (60) days;
wherein, the treatment reduces the incidence of edema in the mammal administered Celecoxib and lisinopril as compared to a mammal administered celecoxib alone by at least 17%.
40 . The method of claim 39 , wherein the dose of celecoxib and lisinopril in a single dosage unit is 100 mg celecoxib and 40 mg lisinopril, 200 mg celecoxib and 40 mg lisinopril, 100 mg celecoxib and 5 mg lisinopril, or 200 mg celecoxib and 5 mg lisinopril.