Tissue filler compositions and methods of use

1. A method for stimulating collagen synthesis comprising:

administering a composition to an area to be treated within a soft tissue, wherein the composition comprises a tissue filler medium, Eosin Y, and Fluorescein; and

illuminating the area to be treated with light having a wavelength which can be absorbed by Eosin Y and Fluorescein;

wherein the method stimulates collagen synthesis in the area to be treated.

2. A method for cosmetic enhancement of soft tissue comprising:

intradermally or subdermally administering a composition to an area to be treated, wherein the composition comprises a tissue filler medium, Eosin Y, and Fluorescein; and

illuminating the area to be treated with light having a wavelength which can be absorbed by Eosin Y and Fluorescein;

wherein the method stimulates collagen synthesis in the area to be treated to cosmetically enhance the soft tissue.

3. The method of claim 1 , wherein the area to be treated is soft tissue.

4. The method of claim 1 , wherein the administering of the composition is by injection.

5. The method of claim 1 , wherein the administering of the composition is by implantation.

6. The method of claim 1 or 2 , wherein the composition is selected from a cohesive gel and a hydrated gel.

7. The method of claim 1 or 2 , wherein the tissue filler is a dermal filler.

8. The method of claim 1 or 2 , wherein the tissue filler medium comprises a polymer.

9. The method of claim 8 , wherein the polymer is selected from proteins, peptides, polypeptides, polylysine, collagens, pro-collagens, elastins, and laminins.

10. The method of claim 8 , wherein the polymer is selected from poly(vinyl alcohol), polyethylene glycol, polyvinlyl amine, polyallylamine, deacetylated polyacrylamide, polyacrylic acid, and polymethacrylic acid.

11. The method of claim 1 or 2 , wherein the tissue filler medium comprises cross-linked hyaluronic acid.

12. The method of claim 1 or 2 , wherein the composition further comprises light reflecting particles.

13. The method of claim 2 , wherein intradermally or subdermally administering comprises providing a track of composition from external to the dermis to the composition.

14. A tissue filler composition comprising:

a tissue filler medium; and

at least Eosin Y and Fluorescein;

wherein the composition is suitable for injection or implantation into a human.

15. The composition of claim 14 , wherein the composition is a cohesive gel.

16. The composition of claim 14 , wherein the composition is a hydrated gel.

17. The composition of claim 14 , wherein the composition is transparent or translucent.

18. The composition of claim 14 , wherein the tissue filler medium retains Eosin Y and Fluorescein within the composition during administering of the composition, and at least during a portion of the illumination.

19. The composition of claim 14 , wherein the tissue filler medium is biodegradable.

20. The composition of claim 14 , wherein the tissue filler medium comprises cross-linked hyaluronic acid.

21. The composition of claim 20 , wherein the cross-linked hyaluronic acid is in particulate form.

22. The composition of claim 14 , wherein the composition further comprises an injectable medium supporting the particles.

23. The composition of claim 14 , wherein the injectable medium comprises hyaluronic acid which is relatively less cross-linked than the hyaluronic acid in particulate form.

24. The composition of claim 14 , wherein the composition further comprises light reflecting particles.

25. The composition of claim 14 , wherein Eosin Y and Fluorescein can be activated by light having a wavelength in the visible range.

26. The composition of claim 14 , wherein Eosin Y and Fluorescein are not in a liposomal form in the composition.