IP Library › Granted Patent US 10,548,928
Granted Patent B2
US 10,548,928 · App. 15/303,418 · Granted Feb 4, 2020

Use of

Inventors: Gianfranco Grompone (Paris, FR); Muriel Derrien (Bures sur Yvette, FR); Johan Van Hylckama Vlieg (Chavenay, FR); Pascale Serror (Jouy-en-josas, FR); Lionel Rigottier-Gois (Palaiseau, FR); Laureen Crouzet (Blanzat, FR); Claire Cherbuy (Les Ulis, FR)
Assignees: COMPAGNIE GERVAIS DANONE; INSTITUT NATIONAL DE LA RECHERCHE AGRNOMIQUE
A61K35/747A23C9/1234A23L33/135C12R1/225A23V2002/00A23Y2220/63
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Quick Facts
Patent No.
US 10,548,928
App. No.
15/303,418
Granted
Feb 4, 2020
Kind
B2
Abstract

The present invention provides the use of Lactobacillus paracasei , for maintaining or increasing the intestinal microbiota diversity in a subject having dysbiosis.

Claims (6)

1. A method to treat an infection caused by a vancomycin-resistant Enterococcus faecalis in the intestinal microbiota of a subject having a dysbiosis caused by or subsequent to antibiotic treatment of said subject, comprising administering Lactobacillus paracasei subspecies paracasei strain CNCM I-3689 to said subject.

2. The method according to claim 1 , wherein said Enterococcus faecalis are further resistant to antibiotics selected from penicillins, cephalosporins, fluoroquinolones, aminoglycosides, and glycopeptides.

3. The method according to claim 1 , wherein said Enterococcus faecalis are part of a High-Risk Enterococcal Clonal Complex.

4. The method according to claim 1 , wherein said Lactobacillus paracasei is in an orally administrable composition.

5. The method according to claim 4 , wherein said composition is a fermented dairy product.

6. The method according to claim 1 , wherein said dysbiosis is characterized by an increase in Firmicutes.

Assignments (2)
CHANGE OF NAME Recorded Jan 12, 2021
From: INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA)
To: INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT
Reel/Frame 054972/0888 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 8, 2017
From: GROMPONE, GIANFRANCO; DERRIEN, MURIEL; VAN HYLCKAMA VLIEG, JOHAN; SERROR, PASCALE; RIGOTTIER-GOIS, LIONEL; CROUZET, LAUREEN; CHERBUY, CLAIRE
To: COMPAGNIE GERVAIS DANONE; INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE
Reel/Frame 044792/0941 →
Cited By (2)
US 12,292,059 US 12,428,917