Capsule shells comprising an esterified cellulose ether
View Patent ↗A polymeric capsule shell of high quality is prepared from an aqueous composition which comprises (A) at least one esterified cellulose ether comprising aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOH, R being a divalent aliphatic or aromatic hydrocarbon group, wherein at least a part of the groups —C(O)—R—COOH are neutralized with an ammonium salt of carbonic acid, formic acid or acetic acid, and (B) from 0 to 7 weight percent of a non-polymeric plasticizer, based on the weight of the esterified cellulose ether, wherein the weight of said at least one esterified cellulose ether is at least 80 percent of the total polymer weight in the aqueous composition.
1. A polymeric capsule shell comprising
(A) a hydroxypropyl methyl cellulose acetate succinate, wherein a part of the succinoyl groups are neutralized with an ammonium salt of carbonic acid, formic acid or acetic acid,
(B) from 0 to 7 weight percent of a non-polymeric plasticizer, based on the weight of the hydroxypropyl methyl cellulose acetate succinate, and
(C) from 0 to 1 weight percent of a dispersant, based on the total weight of the hydroxypropyl methyl cellulose acetate succinate,
wherein the weight of said hydroxypropyl methyl cellulose acetate succinate is at least 80 percent of the total polymer weight in the capsule shell.
2. The capsule shell of claim 1 wherein the weight of said hydroxypropyl methyl cellulose acetate succinate is at least 85 percent of the total polymer weight in the capsule shell.
3. The capsule shell of claim 1 comprising hydroxypropyl methyl cellulose acetate succinate that is partially neutralized with ammonium carbonate or ammonium hydrogen carbonate.
4. The capsule shell of claim 1 additionally comprising at least one adjuvant selected from the group consisting of gelling agents, coloring agents, pigments, opacifiers, flavor and taste improvers, and antioxidants.
5. The capsule shell of claim 1 being a hard capsule shell.
6. A capsule comprising a capsule shell of claim 1 and further comprising a drug or a nutritional or food supplement or a combination thereof.
7. A polymeric capsule shell prepared from an aqueous composition comprising
(A) a hydroxypropyl methyl cellulose acetate succinate, wherein at least 50 mol percent of the succinoyl groups are neutralized with an ammonium salt of carbonic acid, formic acid or acetic acid such that the hydroxypropyl methyl cellulose acetate succinate is soluble in the aqueous composition,
(B) from 0 to 7 weight percent of a non-polymeric plasticizer, based on the weight of the hydroxypropyl methyl cellulose acetate succinate, and
(C) from 0 to 1 weight percent of a dispersant, based on the total weight of the hydroxypropyl methyl cellulose acetate succinate,
wherein the weight of said hydroxypropyl methyl cellulose acetate succinate is at least 80 percent of the total polymer weight in the aqueous composition.
8. The polymeric capsule shell of claim 7 prepared from an aqueous composition comprising a hydroxypropyl methyl cellulose acetate succinate, wherein at least 75 mole percent of the succinoyl groups are neutralized with an ammonium salt of carbonic acid, formic acid or acetic acid.
9. A process for producing polymeric capsule shells comprising the steps of
providing an aqueous composition comprising (A) a hydroxypropyl methyl cellulose acetate succinate, wherein the succinoyl groups are fully or partially neutralized to such extent with an ammonium salt of carbonic acid, formic acid or acetic acid such that at least 50 mol percent of the succinoyl groups are neutralized and that the hydroxypropyl methyl cellulose acetate succinate is soluble in the aqueous composition, (B) from 0 to 7 weight percent of a non-polymeric plasticizer, based on the weight of the hydroxypropyl methyl cellulose acetate succinate, and (C) from 0 to 1 weight percent of a dispersant, based on the total weight of the hydroxypropyl methyl cellulose acetate succinate, wherein the weight of said hydroxypropyl methyl cellulose acetate succinate is at least 80 percent of the total polymer weight in the aqueous composition,
dipping molding pins into the aqueous composition,
forming a film on said molding pins by withdrawing said pins from said aqueous composition, and
drying the film on the molding pins.
10. The process of claim 9 which comprises the steps of
pre-heating molding pins to a temperature higher than the aqueous composition,
dipping the pre-heated molding pins into the aqueous composition,
forming a film on said molding pins by withdrawing said pins from said aqueous composition, and
drying the film on the molding pins.
11. The process of claim 10 wherein the film on the molding pins is dried at a temperature of at least 60° C. to partially remove the ammonium salt of carbonic acid, formic acid or acetic acid or its decomposition products from the produced capsule shells.
12. The process of claim 9 which comprises the steps of
providing an aqueous composition which additionally comprises a gelling agent,
pre-heating the aqueous composition to a temperature higher than the molding pins,
dipping the molding pins into the pre-heated aqueous composition,
forming a film on said molding pins by withdrawing said pins from said aqueous composition, and
drying the film on the molding pins.
13. The process of claim 12 wherein the film on the molding pins is dried at a temperature of at least 60° C. to partially remove the ammonium salt of carbonic acid, formic acid or acetic acid or its decomposition products from the produced capsule shells.
14. The process of claim 9 wherein the weight of the hydroxypropyl methyl cellulose acetate succinate is at least 85 percent of the total polymer weight in the capsule shell.
15. The process of claim 9 wherein at least 75 mole percent of the succinoyl groups are neutralized with an ammonium salt of carbonic acid, formic acid or acetic acid.
16. The process of claim 9 wherein the pH of the aqueous composition is at least 5.5.