Methods and compositions comprising 10-hydroxy-2-decenoic acid
View Patent ↗Disclosed herein are compositions for use in treating anxiety, inflammatory conditions, fertility-related disorders, for increasing cognitive performance and managing weight comprising 10-Hydroxy-2-decenoic acid or a derivative thereof and preferably at least one polyunsaturated fatty acid. The preferred polyunsaturated fatty acid is DHA.
1. A composition comprising 10-Hydroxy-2-decenoic acid or a derivative thereof, and at least one polyunsaturated fatty acid (PUFA), wherein the PUFA is administered in an amount of about 100 mg/day to about 4000 mg/day, for use in treating anxiety, fertility-related disorders, inflammatory conditions, improving cognitive performance, or managing weight.
2. The composition for use of claim 1 , wherein the PUFA is an omega-3 fatty acid.
3. The composition for use according to claim 1 , wherein the 10-Hydroxy-2-decenoic acid is administered in an amount of about 0.2 mg/day to about 5000 mg/day.
4. A composition according to claim 1 for use in treating anxiety.
5. A composition according to claim 1 for use in treating fertility-related disorders.
6. The composition for use according to claim 5 , wherein the fertility-related disorder comprises idiosyncratic infertility, polycystic ovarian syndrome and primary ovarian insufficiency.
7. A composition according to claim 1 for use in treating an inflammatory condition.
8. The composition for use according to claim 7 , wherein the inflammatory condition comprises a gastrointestinal tract disorder.
9. The composition for use according to claim 7 , wherein the inflammatory condition is colitis.
10. A composition according to claim 1 for use in increasing cognitive performance.
11. A composition according to claim 1 for managing weight.
12. The composition for use according to claim 11 , wherein the managing weight is maintaining weight in a subject having a diseased state.
13. The composition for use according to claim 11 , wherein the managing weight is weight loss.
14. The composition for use according to claim 13 , wherein the weight loss is associated with aging.
15. The composition for use according to claim 13 , wherein the weight loss is associated with stress.
16. Composition for use according to claim 1 , wherein the composition is used for treatment of a human.
17. Composition for use according to claim 1 , wherein the 10-Hydroxy-2-decenoic acid is in the form of a free fatty acid or salt thereof.
18. Composition for use according to claim 17 , wherein the PUFA is in the form of an ethyl ester or a glyceride ester.
19. A composition comprising about 0.2 mg to about 5000 mg 10-Hydroxy-2-decenoic acid and about 100 mg to about 4000 mg DHA.
20. A composition according to claim 19 , wherein the composition is in the form of one or more capsules.
21. A method of treating anxiety, fertility-related disorders, inflammatory conditions, improving cognitive performance, or managing weight in a subject in need thereof, comprising administering a therapeutically effective amount of 10-Hydroxy-2-decenoic acid or a derivative thereof, and at least one polyunsaturated fatty acid (PUFA).
22. The composition for use of claim 2 , wherein the PUFA is docosahexaenoic acid (DHA).
23. A composition comprising about 12 mg to about 300 mg 10-Hydroxy-2-decenoic acid and about 100 mg to about 1500 mg DHA.
24. A composition according to claim 23 , wherein the 10-Hydroxy-2-decenoic acid is in the form of a free fatty acid or salt thereof.
25. A composition according to claim 23 or claim 24 , wherein the DHA is in the form of an ethyl ester or a glyceride ester.