Compounds
The present invention relates to novel retinoid-related orphan receptor gamma (RORγ) modulators and their use in the treatment of diseases mediated by RORγ.
1. A compound of Formula I or a pharmaceutically acceptable salt thereof:
wherein
R 1 is:
5 to 6 membered monocyclic heteroaryl optionally substituted with i) C 1 -C 5 alkyl optionally substituted with CF 3 or CN, ii) CH 2 F; or iii) one to two substituents independently selected from the group consisting of halo, methyl, methoxy and CN; wherein said 5 to 6 membered monocyclic heteroaryl is selected from the group consisting of pyrrolyl, pyrazolyl, imidazolyl, oxazolyl, isoxazolyl, oxadiazolyl, thiazolyl, isothiazolyl, thiadiazolyl, furanyl, furazanyl, thienyl, triazolyl, pyridinyl, pyrimidinyl, pyridazinyl, pyrazinyl, triazinyl, tetrazinyl, and tetrazolyl, or N-oxides thereof; or
phenyl substituted with one to two substituents independently selected from the group consisting of CN, halo and methyl;
R 2 is C 1 -C 3 alkyl;
R 3 is halo,
R 4 is H;
R 5 is C 1 -C 3 alkyl,
R 6 is H or methyl; and
R 7 is tetrahydrofuranyl or tetrahydropyranyl, wherein said tetrahydrofuranyl or tetrahydropyranyl is optionally substituted with methyl.
2. The compound or salt according to claim 1 , wherein R 1 is phenyl substituted with CN.
3. The compound or salt according to claim 1 , wherein R 1 is phenyl substituted with CN and F.
4. The compound or salt according to any of claim 1 , wherein R 1 is pyridinyl substituted with i) methyl and F; ii) methyl and Cl; iii) methyl and CN; or iv) CN and F.
5. The compound or salt according to any of claim 1 , wherein R 1 is pyridinyl substituted with i) methyl and F.
6. The compound or salt according to claim 1 , wherein R 2 is methyl.
7. The compound or salt according to claim 1 , wherein R 3 is Cl.
8. The compound or salt according to claim 1 , wherein R 5 is methyl.
9. The compound or salt according to claim 1 , wherein R 6 is H.
10. The compound or salt according to claim 1 , wherein R 7 is tetrahydrofuranyl.
11. The compound or salt according to claim 1 , wherein R 7 is tetrahydropyranyl.
12. The compound according to claim 1 selected from the group consisting of:
(S)—N-(5-chloro-2-methyl-3-((3-methyl-4-(tetrahydro-2H-pyran-4-carbonyl)piperazin-1-yl)methyl)phenyl)-3-cyanobenzamide;
N-(5-chloro-2-methyl-3-(((S)-3-methyl-4-((R)-tetrahydrofuran-2-carbonyl)piperazin-1-yl)methyl)phenyl)-3-cyano-5-fluorobenzamide,
N-(5-chloro-2-methyl-3-(((S)-3-methyl-4-((S)-tetrahydrofuran-2-carbonyl)piperazin-1-yl)methyl)phenyl)-3-cyano-5-fluorobenzamide,
N-(5-chloro-2-methyl-3-(((S)-3-methyl-4-((R)-tetrahydrofuran-2-carbonyl)piperazin-1-yl)methyl)phenyl)-3-cyanobenzamide;
N-(5-chloro-2-methyl-3-(((S)-3-methyl-4-((R)-tetrahydrofuran-3-carbonyl)piperazin-1-yl)methyl)phenyl)-3-cyanobenzamide;
N-(5-chloro-2-methyl-3-(((S)-3-methyl-4-((S)-tetrahydrofuran-2-carbonyl)piperazin-1-yl)methyl)phenyl)-3-cyanobenzamide;
N-(5-chloro-2-methyl-3-(((S)-3-methyl-4-((S)-tetrahydrofuran-3-carbonyl)piperazin-1-yl)methyl)phenyl)-3-cyanobenzamide,
N-(5-chloro-2-methyl-3-(((S)-3-methyl-4-((R)-tetrahydrofuran-2-carbonyl)piperazin-1-yl)methyl)phenyl)-3-cyano-4-fluorobenzamide;
N-(5-chloro-2-methyl-3-(((S)-3-methyl-4-((S)-tetrahydrofuran-2-carbonyl)piperazin-1-yl)methyl)phenyl)-3-cyano-4-fluorobenzamide,
N-(5-chloro-2-methyl-3-(((S)-3-methyl-4-((R)-tetrahydrofuran-2-carbonyl)piperazin-1-yl)methyl)phenyl)-5-fluoro-6-methylnicotinamide;
N-(5-chloro-2-methyl-3-(((S)-3-methyl-4-((S)-tetrahydrofuran-2-carbonyl)piperazin-1-yl)methyl)phenyl)-5-fluoro-6-methylnicotinamide;
N-(5-chloro-2-methyl-3-(((S)-3-methyl-4-((R)-tetrahydrofuran-2-carbonyl)piperazin-1-yl)methyl)phenyl)-5-cyano-6-methylnicotinamide;
N-(5-chloro-2-methyl-3-(((S)-3-methyl-4-((S)-tetrahydrofuran-2-carbonyl)piperazin-1-yl)methyl)phenyl)-5-cyano-6-methylnicotinamide,
N-(5-chloro-2-methyl-3-(((S)-3-methyl-4-((R)-tetrahydrofuran-3-carbonyl)piperazin-1-yl)methyl)phenyl)-5-fluoro-6-methylnicotinamide,
N-(5-chloro-2-methyl-3-(((S)-3-methyl-4-((S)-tetrahydrofuran-3-carbonyl)piperazin-1-yl)methyl)phenyl)-5-fluoro-6-methylnicotinamide;
5-chloro-N-(5-chloro-2-methyl-3-(((S)-3-methyl-4-((S)-tetrahydrofuran-2-carbonyl)piperazin-1-yl)methyl)phenyl)-6-methylnicotinamide; and
5-chloro-N-(5-chloro-2-methyl-3-(((S)-3-methyl-4-((R)-tetrahydrofuran-2-carbonyl)piperazin-1-yl)methyl)phenyl)-6-methylnicotinamide
or a pharmaceutically acceptable salt thereof.
13. The compound according to claim 1 selected from the group consisting of:
N-(5-chloro-2-methyl-3-(((S)-3-methyl-4-((S)-tetrahydrofuran-2-carbonyl)piperazin-1-yl)methyl)phenyl)-5,6-dimethylnicotinamide;
N-(5-chloro-2-methyl-3-(((S)-3-methyl-4-((R)-tetrahydrofuran-3-carbonyl)piperazin-1-yl)methyl)phenyl)-5-cyano-6-methylnicotinamide,
N-(5-chloro-2-methyl-3-(((S)-3-methyl-4-((S)-tetrahydrofuran-3-carbonyl)piperazin-1-yl)methyl)phenyl)-5-cyano-6-methylnicotinamide;
N-(5-chloro-2-methyl-3-(((S)-3-methyl-4-((R)-tetrahydrofuran-3-carbonyl)piperazin-1-yl)methyl)phenyl)-5-methoxy-6-methylnicotinamide;
N-(5-chloro-2-methyl-3-(((S)-3-methyl-4-((S)-tetrahydrofuran-3-carbonyl)piperazin-1-yl)methyl)phenyl)-5-methoxy-6-methylnicotinamide,
N-(5-chloro-2-methyl-3-(((R)-3-methyl-4-((R)-tetrahydrofuran-2-carbonyl)piperazin-1-yl)methyl)phenyl)-5-fluoro-6-methylnicotinamide;
N-(5-chloro-2-methyl-3-(((R)-3-methyl-4-((S)-tetrahydrofuran-2-carbonyl)piperazin-1-yl)methyl)phenyl)-5-fluoro-6-methylnicotinamide;
N-(5-chloro-2-methyl-3-(((R)-3-methyl-4-((S)-tetrahydrofuran-3-carbonyl)piperazin-1-yl)methyl)phenyl)-5-fluoro-6-methylnicotinamide,
N-(5-chloro-2-methyl-3-(((R)-3-methyl-4-((R)-tetrahydrofuran-3-carbonyl)piperazin-1-yl)methyl)phenyl)-5-fluoro-6-methylnicotinamide; and
5-((5-chloro-2-methyl-3-(((S)-3-methyl-4-((R)-tetrahydrofuran-3-carbonyl)piperazin-1-yl)methyl)phenyl)carbamoyl)-3-fluoro-2-methylpyridine 1-oxide;
or a pharmaceutically acceptable salt thereof.
14. The compound according to claim 1 which is N-(5-chloro-2-methyl-3-(((S)-3-methyl-4-((S)-tetrahydrofuran-3-carbonyl)piperazin-1-yl)methyl)phenyl)-5-fluoro-6-methylnicotinamide, or a pharmaceutically acceptable salt thereof.
15. The compound according to claim 1 which is N-(5-chloro-2-methyl-3-(((S)-3-methyl-4-((R)-tetrahydrofuran-3-carbonyl)piperazin-1-yl)methyl)phenyl)-5-fluoro-6-methylnicotinamide, or a pharmaceutically acceptable salt thereof.
16. A pharmaceutical composition which comprises the compound of Formula I according to claim 1 or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier or excipient.
17. A method of treating multiple sclerosis comprising administering to a human in need thereof an effective amount of the compound or pharmaceutically acceptable salt according to claim 1 .
18. A method of treating ankylosing spondylitis comprising administering to a human in need thereof an effective amount of the compound or pharmaceutically acceptable salt according to claim 1 .
19. The pharmaceutical composition according to claim 16 , wherein the compound of Formula I is N-(5-chloro-2-methyl-3-(((S)-3-methyl-4-((S)-tetrahydrofuran-3-carbonyl)piperazin-1-yl)methyl)phenyl)-5-fluoro-6-methylnicotinamide or a pharmaceutically acceptable salt thereof.
20. The method of t eating multiple sclerosis according to claim 17 , wherein the compound is N-(5-chloro-2-methyl-3-(((S)-3-methyl-4-((S)-tetrahydrofuran-3-carbonyl)piperazin-1-yl)methyl)phenyl)-5-fluoro-6-methylnicotinamide or a pharmaceutically acceptable salt thereof.
21. The method of treating ankylosing spondylitis according to claim 18 , wherein the compound of is N-(5-chloro-2-methyl-3-(((S)-3-methyl-4-((S)-tetrahydrofuran-3-carbonyl)piperazin-1-yl)methyl)phenyl)-5-fluoro-6-methylnicotinamide or a pharmaceutically acceptable salt thereof.