Antimicrobial-antibiofilm compositions and methods of use thereof for personal care products

1. A composition for inhibiting growth of Methicillin -resistant Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus agalactiae ATCC 12386, Acinetobacter baumannii, Stenotrophomonas maltophilia , Vancomycin-resistant Enterococci, or Proteus mirabilis , or for inhibiting biofilm formation by Methicillin -resistant Staphylococcus aureus, Methicillin -resistant Staphylococcus pseudintermedius, Pseudomonas aeruginosa, Salmonella choleraesuis ATCC 10708, Escherichia coli 0157:H7, Staphylococcus epidermidis , Coagulase-negative Staphylococci, Streptococcus agalactiae ATCC 12386, Klebsiella pneumoniae, Acinetobacter baumannii, Stenotrophomonas maltophilia, Vancomycin -resistant Enterococci, Enterococcus faecalis, Proteus mirabilis , or Malassezia pachydermatis , the composition comprising:

(a) water;

(b) one or more chelating agents selected from the group consisting of disodium or tetrasodium EDTA at a concentration of about 125 to 250 mg/L,

(c) one or more chelating agents selected from the group consisting of sodium citrate, and potassium citrate, at a concentration of about 3,000 mg/L; and optionally

(d) a zinc salt selected from the group consisting of zinc chloride, zinc gluconate, zinc lactate, zinc citrate, zinc sulfate, and zinc acetate.

2. The composition of claim 1 , wherein the zinc salt is zinc chloride or zinc citrate.

3. The composition of claim 1 , wherein the composition comprises:

(i) disodium EDTA and sodium citrate, or

(ii) sodium citrate, disodium EDTA and zinc chloride.

4. The composition of claim 1 , further comprising an antimicrobial preservative selected from one or more of potassium sorbate, potassium benzoate, sodium benzoate and benzoic acid.

5. The composition of claim 1 , further comprising one or more ingredients selected from the group consisting of: water, a buffer, a stabilizing agent, a gelling agent, a surfactant, a herbal, a vitamin, a mineral, an extra cellular matrix, an antimicrobial, an antibiotic, and a pH adjuster.

6. The composition of claim 1 prepared as one or more of a disinfecting solution, a dip solution, a lotion, a cream, an ointment, a gel, and a spray.

7. The composition as claimed in claim 1 , wherein the composition comprises a liposome or nanoparticle or a suitable device delivery system.

8. The composition as claimed in claim 1 , further comprising an anti-infective compound selected from the group consisting of glycoside hydrolase of Aggregatibacter actinomycetemcomitans , alginate lyase, nisin, lactoferricin, serotransferrin, ovotransferrin, ovalbumin, ovomucoid, protamine sulfate, chlorhexidine, cetylpyridinium chloride, triclosan, silver sulfadiazine, benzalkonium chloride, hydrogen peroxide, citric acid, potassium citrate, 5-fluorouracil, cis-2-decenoic acid, DNase I, proteinase K, silver, gallium, silver, bacteriocins and antimicrobial peptides.

9. The composition as claimed in claim 1 further comprising one or more of viscosity enhancing agents, lubricants, surfactants, buffers, preservatives, and salts.

10. The composition as claimed in claim 1 , wherein the composition is selected from a solution, a gel, a cream, a jelly, a powder, a paste, a lotion, a soap and a cleaner.

11. A method of preventing or treating ophthalmic biofilm growth, the method comprising administering the composition of claim 1 to the eye of a user.

12. A method of preventing or treating hand or feet biofilm growth, the method comprising administering the composition of 1 to a foot, fingernail, or toenail of a user.

13. A personal care device treated or impregnated with the composition of claim 1 .

14. The personal care device of claim 13 , comprising one or more of a contact lens and a contact lens container.

15. The personal care device of claim 13 , comprising one or more of a hand washing container, a scrubber, and a foot washing container.