IP Library Granted Patent US 10,173,215
Granted Patent B2
US 10,173,215 · App. 15/322,751 · Granted Jan 8, 2019

Flow cell comprising a storage zone and a duct that can be opened at a predetermined breaking point

Inventor: Lutz Weber (Zweibrücken, DE)
Assignee: THINXXS MICROTECHNOLOGY AG
B01L3/502738B01L3/50273B01L3/502707B01L3/523B01L2200/0689B01L2300/0816B01L2300/0887B01L2300/123B01L2400/0481B01L2400/0487B01L2400/0655
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Quick Facts
Patent No.
US 10,173,215
App. No.
15/322,751
Granted
Jan 8, 2019
Kind
B2
Abstract

A flow cell having at least one storage zone connected to a duct for conducting fluid out of, into or/and through the storage zone. The duct includes a duct section which is delimited by a substrate and a film joined to the substrate and in which the duct is sealed and can be opened at a predetermined breaking point by deflecting the film. The film covers a recess in the substrate which forms the duct section. A sealing wall that seals the duct and is integrally joined to the substrate is placed in the recess. The predetermined breaking point is formed by a breakable joining region between the film and an edge portion of the sealing wall facing the film. The dimensions of a peripheral area of the sealing wall which is formed in the edge portion and runs parallel to the film determine the surface area of the joining region.

Claims (20)

1. A flow cell, comprising: a duct; at least one storage zone connected to the duct for transporting fluid from, into, or/and through the storage zone in a flow direction, wherein the duct has a duct zone delimited by a substrate and by a film connected to the substrate, in the duct zone the duct is closed off and at a predetermined breaking point is openable while deflecting the film, wherein the film covers a clearance in the substrate that forms the duct zone; and a barrier wall disposed in the clearance and integrally connected to the substrate and shuts off the duct, the predetermined breaking point is formed by a rupturable connection zone between the film and a peripheral portion of the barrier wall that faces the film, wherein the barrier wall has a thickness, measured in a direction perpendicular to a planar extent of the film, that decreases toward the film, dimensions of a peripheral area of the barrier wall that is parallel with the film and is formed in the peripheral portion are relevant to a planar extent of the connection zone.

2. The flow cell according to claim 1 , wherein the peripheral area approximates a line that is perpendicular to the flow direction.

3. The flow cell according to claim 1 , wherein the barrier wall is a barrier web that traverses the clearance, and said barrier web is connected to the substrate at ends of the barrier web and on the peripheral portion that is opposite the peripheral area.

4. The flow cell according to claim 1 , wherein the barrier wall, in cross section, is configured to be triangular or segment-shaped.

5. The flow cell according to claim 4 , wherein the barrier wall has a flattening that faces the film.

6. The flow cell according to claim 1 , wherein the peripheral area of the barrier wall that is parallel with the film has a bulge that protrudes counter to the flow direction.

7. The flow cell according to claim 1 , wherein the duct, in the duct zone that has the predetermined breaking point, in relation to duct zones that are adjacent to the duct zone with the predetermined breaking point in the flow direction, is widened or constricted in cross section.

8. The flow cell according to claim 1 , wherein the duct is rupturable by a fluid pressure that bears on the predetermined breaking point in the flow direction, or by way of mechanical or/and pneumatic deflection of the film.

9. The flow cell according to claim 1 , wherein the film at the peripheral area of the barrier wall is adhesively bonded and/or welded to the barrier wall.

10. The flow cell according to claim 1 , wherein the film is clamped to the peripheral area of the barrier wall by a movable clamping element that is connected to the flow cell.

11. The flow cell according to claim 1 , wherein the substrate is plate-shaped and the clearance is open toward a planar area of the plate-shaped substrate.

12. The flow cell according to claim 1 , wherein the predetermined breaking point lies in a projection zone of the storage zone, the projection zone being for a projection perpendicular to a planar area.

13. The flow cell according to claim 1 , wherein the duct has a plurality of predetermined breaking points, wherein a drying reagent is enclosed between two predetermined breaking points.

14. The flow cell according to claim 1 , wherein the storage zone is delimited by the substrate and a film thermoformed in the storage zone and disposed on one side of the substrate, and is connected to the duct zone by a duct portion, and the film that delimits the duct zone is disposed on the other side of the substrate.

15. The flow cell according to claim 14 , wherein the film that delimits the storage zone is an aluminum-plastics laminate having a plastics layer that faces the storage zone.

16. The flow cell according to claim 14 , wherein at least one side of the substrate has a surface structure that facilitates connection to the film.

17. The flow cell according to claim 16 , wherein the surface structure includes trenches.

18. The flow cell according to claim 1 , wherein the film that delimits the duct zone is a plastics film.

19. The flow cell according to claim 1 , wherein the plastics film is covered by an aluminum-plastics laminate.

20. The flow cell according to claim 13 , wherein the film that delimits the duct zone is a contiguous film that delimits a plurality of storage zones.

Assignments (2)
CHANGE OF NAME Recorded May 18, 2022
From: THINXXS MICROTECHNOLOGY AG
To: THINXXS MICROTECHNOLOGY GMBH
Reel/Frame 060383/0572 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 29, 2016
From: WEBER, LUTZ
To: THINXXS MICROTECHNOLOGY AG
Reel/Frame 040797/0967 →
Priority Claims (1)
EP 14175207 · Jul 1, 2014 · regional
Continuity (1)
Related Publication 20170157608A1 · Jun 8, 2017
Cited By (8)
US 1,072,635 US 1,072,636 US 1,072,637 US 1,072,638 US 1,073,491 US 1,086,898 US 1,095,884 US 12,310,730