Method and device for functional imaging of the brain

1. A method for functional imaging of the brain by ultrasonic waves, comprising the following steps:

an atlas producing step during which a brain vascular atlas and a brain functional atlas are produced by

using at least one imaging technique to produce the brain vascular atlas of at least one subject from a certain class of subjects to be considered,

using a second type of imaging on the brain of the at least one subject giving a more accurate anatomic image of the brain than ultrasonic imaging to produce a reference anatomic atlas,

producing the brain functional atlas by matching the reference anatomic atlas with a functional anatomic atlas comprising a typical anatomic atlas having functional areas located on this typical anatomic atlas in order to locate the functional areas of the functional anatomic atlas on said brain vascular atlas,

a vascular imaging step during which a brain of a human or animal subject is imaged by ultrasonic imaging, in order to obtain a vascular image to be studied from which one or more of blood vessels and microvessels are viewable, said subject belonging to the certain class of subjects,

a localization step, during which, by shape recognition, at least one portion of the vascular image to be studied is automatically compared with at least one portion of the brain vascular atlas corresponding to said class of subjects, and the vascular image to be studied is thereby located in the brain vascular atlas,

an identification step during which the brain functional atlas corresponding to said brain vascular atlas and comprising the functional areas located in this brain vascular atlas is used, wherein a map of functional areas corresponding to said portion of the brain vascular atlas is determined, and the vascular image to be studied is superposed with said map of functional areas so that at least one brain functional area is identified on the vascular image to be studied.

2. The method according to claim 1 , wherein, during the localization step, a geometrical deformation is determined giving the possibility of passing from said at least one portion of the brain vascular atlas to the vascular image to be studied, and during the identification step, the functional map of the vascular image to be studied is determined by applying this geometrical deformation to a portion of the brain functional atlas corresponding to said portion of the brain vascular atlas which corresponds to the vascular image to be studied.

3. The method according to claim 1 , wherein in the localization step, said shape recognition is carried out by correlation between the vascular image to be studied and the brain vascular atlas.

4. The method according to claim 1 , wherein the vascular image to be studied includes at least one piece of hemodynamic information selected from among: brain vascular volume, Doppler power, flow rate of blood, Doppler color, a value representative of circulation resistance.

5. The method claim 1 , wherein the brain vascular atlas contains data stemming from an imaging selected from among ultrasonic imaging, angioscanner, MRI, and a CT scanner.

6. The method according to claim 1 , further comprising, between the imaging step and the localization step, a preliminary localization step during which on the vascular image to be studied, at least one characteristic area normally present in any subject to be studied and in the brain vascular atlas is automatically detected, and the vascular image to be studied is thus roughly located in the brain vascular atlas.

7. The method according to claim 6 , wherein said characteristic area is selected from among Willis polygon, Sylvian veins, anterior brain artery, and largest arteries of the brain.

8. The method according to claim 1 , wherein said brain vascular atlas is produced by vascular ultrasonic imaging of the brain.

9. The method according to claim 1 , wherein the reference anatomic atlas is matched with the typical anatomic atlas by shape recognition.

10. The method according to claim 9 , wherein a geometrical deformation is determined which gives the possibility of passing from said reference anatomic atlas to the typical anatomic atlas, this geometrical deformation is applied to the brain vascular atlas and the brain vascular atlas is thus matched with the functional areas of the functional anatomic atlas.

11. The method according to claim 1 , wherein several initial vascular images are successively carried out by vascular ultrasonic imaging of the brain and several initial anatomic images by said second type of imaging, are successively carried out on several subjects of the class of considered subjects, and said brain vascular atlas and said reference anatomic atlas are determined by a statistical calculation respectively from said initial vascular images and from initial anatomic images.

12. The method according to claim 1 , wherein each class of subjects corresponds to at least one criterion selected from among: species, gender, age, and weight.

13. The method according to claim 1 , wherein a stimulus is applied to the subject and on the brain vascular image an activation of at least one functional area is detected subsequently to this stimulus.

14. The method according to claim 1 , wherein on the brain vascular image, an action targeted towards at least one functional area identified on the brain vascular image is viewed and this action is guided towards said identified functional area.

15. The method according to claim 14 , wherein said action is selected from among an electrode implantation, a fluid injection, a remote stimulation with a wave.

16. The method according to claim 1 , wherein the imaging step is carried out with at least one ultrasonic probe which is configured to be displaced by a motor-driven unit, and said at least one probe is displaced until the brain vascular image corresponds to at least one desired functional area.

17. The method according to claim 1 , wherein the imaging step is carried out with at least one ultrasonic probe adapted for producing a three-dimensional image, and a two-dimensional image corresponding to at least one desired functional area is extracted from this three-dimensional image.